174213-29-7

Basic information

• Product Name: (S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate
• CAS NO: 174213-29-7
• Molecular Weight: 295.354
• Mol File: 174213-29-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate(174213-29-7)
• EPA Substance Registry System: (S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate(174213-29-7)

Safety Data

• Hazardous Substances Data: 174213-29-7(Hazardous Substances Data)

Usage

Description

(S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate is a pyrrolidine derivative featuring a tert-butyl group and a fluoro-substituted phenoxy group. It is an ester compound with a pyrrolidine-1-carboxylate structure, which may have potential applications in the pharmaceutical or agrochemical industries due to its unique structural features and possible biological activities. The (S) configuration denotes the stereochemistry of the molecule, providing specificity to its three-dimensional arrangement. Ongoing research may be exploring its properties and potential uses in various fields.

Uses

Used in Pharmaceutical Industry:
(S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate is used as a potential pharmaceutical compound for its possible biological activities. The specific (S) configuration and the presence of a fluoro-substituted phenoxy group may contribute to its interaction with biological targets, making it a candidate for drug development.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate may be utilized as a precursor or active ingredient in the development of new pesticides or other agrochemical products. Its unique structural features could provide novel modes of action or selectivity for pest control.
Note: The uses listed are speculative based on the information provided and the general knowledge of similar chemical structures. Actual applications may vary and would require further research and development to confirm.

Upstream product

• 372-20-3 3-fluorophenol 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 

Downstream Products

• 871130-52-8 (2S)-(3-fluoro-phenoxymethyl)-pyrrolidine trifluoroacetate 

Relevant articles and documents

In vivo imaging used as isatin deriv.

Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.

PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is -O-, -O(C1-C3 alkyl)-; -(C1-C3 alkyl)O-; -C(O)-; -C(=N-O(C1-C3 alkyl))-; -NH- or -NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, -NH(C1-C3alkyl)-; -N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is convalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid artrhritis, cancer, endometriosis and migraine.

Dpp-IV Inhibitors

The invention relates to compounds of formula (I) wherein R1-9, Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the pre