17433-16-8

Basic information

• Product Name: Quinazoline, 6-chloro-3,4-dihydro-2-methyl-4-phenyl-
• CAS NO: 17433-16-8
• Molecular Formula: C15H13ClN2
• Molecular Weight: 256.735
• Mol File: 17433-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Quinazoline, 6-chloro-3,4-dihydro-2-methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 6-chloro-3,4-dihydro-2-methyl-4-phenyl-(17433-16-8)
• EPA Substance Registry System: Quinazoline, 6-chloro-3,4-dihydro-2-methyl-4-phenyl-(17433-16-8)

Safety Data

• Hazardous Substances Data: 17433-16-8(Hazardous Substances Data)

Upstream product

• 15687-07-7 Cyprazepam 

Relevant articles and documents

Ring contraction of 1,4-benzodiazepines to 3,4-dihydroquinazolines during macro scale reduction (example 5: Cyprazepam)

Cyprazepam (1) is reduced in 3 steps with consumption of 6 Θ at the DME as well as at the stirred Hg-cathode. During these processes ring contraction is observed with formation of 6-chloro-2-methyl-4-phenyl-3,4-dihydroquinazoline accompanied by elimination of cyclopropylmethylamine. This is the fifth example of a reductive ring contraction, which occurs only at a Hg-cathode but not during catalytic hydrogenation.