174460-92-5

Basic information

• Product Name: Benzene, 1-(2-ethoxyethyl)-4-methoxy-
• CAS NO: 174460-92-5
• Molecular Formula: C11H16O2
• Molecular Weight: 180.247
• Mol File: 174460-92-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-ethoxyethyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-ethoxyethyl)-4-methoxy-(174460-92-5)
• EPA Substance Registry System: Benzene, 1-(2-ethoxyethyl)-4-methoxy-(174460-92-5)

Safety Data

• Hazardous Substances Data: 174460-92-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 1796-64-1 4-methoxyphenethyl methyl carbonate 
• 696-62-8 para-iodoanisole 
• 109-92-2 ethyl vinyl ether 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1408168-71-7 potassium (2-ethoxyethyl)trifluoroborate 

Relevant articles and documents

Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes

We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation.

Suzuki-Miyaura cross-coupling of potassium alkoxyethyltrifluoroborates: Access to aryl/heteroarylethyloxy motifs

The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.