174500-74-4

Basic information

• Product Name: (S)-2-Methylpyrrolidine hydrochloride
• Synonyms: (S)-2-METHYL-PYRROLIDINE, HCL;(S)-2-METHYL-PYRROLIDINE HYDROCHLORIDE;Pyrrolidine, 2-methyl-, hydrochloride (1:1), (2S)-;(2S)-2-Methylpyrrolidine hydrochloride
• CAS NO: 174500-74-4
• Molecular Formula: C5H12ClN
• Molecular Weight: 121.61
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline;API intermediates
• Mol File: 174500-74-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 146.9 °C at 760 mmHg
• Flash Point: 42.6 °C
• Appearance: /
• Vapor Pressure: 4.03mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-2-Methylpyrrolidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Methylpyrrolidine hydrochloride(174500-74-4)
• EPA Substance Registry System: (S)-2-Methylpyrrolidine hydrochloride(174500-74-4)

Safety Data

• Hazardous Substances Data: 174500-74-4(Hazardous Substances Data)

Usage

General Description

(S)-2-Methylpyrrolidine hydrochloride, also known as (S)-(+)-2-Methylpyrrolidine hydrochloride, is a chemical compound commonly used as a chiral building block in organic synthesis. It is a white crystalline solid that is soluble in water and has a molecular formula of C5H11N?HCl. (S)-2-Methylpyrrolidine hydrochloride is often utilized in the pharmaceutical industry for the synthesis of various drugs and can also be used as a catalyst in organic reactions. Additionally, (S)-2-Methylpyrrolidine hydrochloride has applications in the production of agrochemicals and specialty chemicals. It is important to handle this compound with care and follow proper safety precautions due to its potential hazards.

InChI:InChI=1/C5H11N.ClH/c1-5-3-2-4-6-5;/h5-6H,2-4H2,1H3;1H/t5-;/m0./s1

Upstream product

• 157007-54-0 2-(R)-methylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 132482-09-8 tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate 
• 338945-22-5 (S)-2-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 43041-12-9 methyl (2R)-pyrrolidine-2-carboxylate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 379229-46-6 (R)-2-(2-methylpyrrolidin-1-yl)ethanol 
• 1260098-08-5 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-morpholin-4-yl-ethanone 
• 1260098-10-9 1-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperidine-4-carbonitrile 
• 1260098-14-3 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-(4-trifluoromethyl-piperidin-1-yl)-ethanone 
• 1260098-11-0 2-(4,4-difluoro-piperidin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-19-8 2-(3,3-difluoro-piperidin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-27-8 2-(3,3-difluoro-pyrrolidin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-30-3 2-(4-acetyl-piperazin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-31-4 2,2,2-trifluoro-1-[4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazin-1-yl]-ethanone 
• 1260098-33-6 2-(4-methanesulfonyl-piperazin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-35-8 2-(4-benzoyl-piperazin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-68-7 2-[4-(4-fluoro-benzoyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-47-2 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-ethanone 
• 1260098-48-3 2-[4-(furan-2-carbonyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 

Relevant articles and documents

Production method of (R)-2-methylpyrrolidine hydrochloride

The invention provides a production method of (R)-2-methylpyrrolidine hydrochloride. The method is an industrial production method and adopts a reduction method of sodium borohydride and different solvents to obtain the (R)-2-methylpyrrolidine hydrochloride with the product purity of 98% or above and the product total yield of 70% or above. Also provided is a process for the synthesis of chiral (R)-2-methylpyrrolidine hydrochloride. Meanwhile, raw materials adopted in the method are easy to obtain, synthesis conditions are simple, the product yield is high, and the method is suitable for industrial production.

MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-receptor associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.

OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. Formula I (I) or a pharmaceutically acceptable salt thereof, wherein: m is independenlly at each occurrence 1, 2, or 3, Z independently represents carbon (substituted with hydrogen or the optional substituents indicated herein) or nitrogen, provided that when Z is nitrogen then R6 is not attached to Z; R1 and R2 are independently -(C1-C7) alkyl(optionally substituted with one to three halogens), or R1 and R2 and the nitrogen to which they are attached form an azetidinyl ring, a pyrrolidinyl ring, or a piperidinyl ring, wherein further the azetidinyl, pyrrolidinyl, or piperidinyl ring so formed may be optionally substituted one to three times with R5; R6 is independently at each occurrence -H, -halogen, or -CH3.