174569-25-6

Basic information

• Product Name: Methoxy-PEG-propionicacid-N-succinimidylester
• Synonyms: MPEGn-SPA 2K, 5K, 10K, 20K;alpha-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-omega-methoxypoly(oxy-1,2-ethanediyl);Methyl-PEGn-NHS (n=12,13,24)
• CAS NO: 174569-25-6
• Molecular Formula: C80H155NO41
• Molecular Weight: 1787.0688
• Product Categories: Polydispersed PEG
• Mol File: 174569-25-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Methoxy-PEG-propionicacid-N-succinimidylester(CAS DataBase Reference)
• NIST Chemistry Reference: Methoxy-PEG-propionicacid-N-succinimidylester(174569-25-6)
• EPA Substance Registry System: Methoxy-PEG-propionicacid-N-succinimidylester(174569-25-6)

Safety Data

• Hazardous Substances Data: 174569-25-6(Hazardous Substances Data)

Usage

Description

Methoxy-PEG-propionicacid-N-succinimidylester is a PEGylated reagent that contains a methoxy-poly(ethylene glycol) (mPEG) group and a propionic acid functional group. The N-succinimidylester group allows for the covalent attachment of the molecule to primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media and provides a versatile platform for the modification and functionalization of biomolecules.

Uses

Used in Bioconjugation:
Methoxy-PEG-propionicacid-N-succinimidylester is used as a bioconjugation agent for the covalent attachment of proteins, peptides, and other amine-containing molecules to various surfaces, nanoparticles, or other biomolecules. The NHS ester reacts with primary amines to form stable amide bonds, facilitating the formation of stable conjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Methoxy-PEG-propionicacid-N-succinimidylester is used as a component in the design of drug delivery systems. The PEGylation of drugs can improve their solubility, stability, and circulation time in the body, leading to enhanced therapeutic efficacy and reduced side effects.
Used in Diagnostics and Imaging:
Methoxy-PEG-propionicacid-N-succinimidylester is used as a labeling agent for the modification of imaging agents, such as fluorescent dyes or radionuclides, for use in diagnostic and imaging applications. The PEG spacer can improve the pharmacokinetics and biodistribution of these agents, enhancing their diagnostic capabilities.
Used in Biosensors and Assays:
In the biotechnology industry, Methoxy-PEG-propionicacid-N-succinimidylester is used as a component in the development of biosensors and assays. The PEGylation of recognition elements, such as antibodies or enzymes, can improve their stability, sensitivity, and performance in various detection platforms.
Used in Tissue Engineering and Regenerative Medicine:
Methoxy-PEG-propionicacid-N-succinimidylester is used as a component in the design of biomaterials and scaffolds for tissue engineering and regenerative medicine applications. The PEGylation of these materials can improve their biocompatibility, reduce immunogenicity, and promote cell adhesion and growth.