1746-32-3 Usage
Description
[(2R,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxo-hexoxy]phosphonic acid, also known as N-acetyl-D-mannosamine-6-phosphate (ManNAc-6P), is a vital chemical compound involved in the biosynthesis of sialic acids. These sialic acids are significant molecules present on the surface of various mammalian cells, where they contribute to cell-cell interactions and signaling processes. ManNAc-6P serves as an intermediate in the sialic acid biosynthetic pathway and plays a role in regulating sialic acid production. [(2R,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxo-hexoxy]phosphonic acid is crucial for the proper functioning of numerous biological processes and holds potential therapeutic applications in diseases related to sialic acid metabolism, as well as in the development of anti-cancer and anti-inflammatory drugs.
Uses
Used in Pharmaceutical Industry:
[(2R,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxo-hexoxy]phosphonic acid is used as a key intermediate in the development of pharmaceuticals for [application reason] the treatment of diseases related to sialic acid metabolism. Its role in the biosynthesis of sialic acids makes it a promising candidate for therapeutic applications.
Used in Cancer Research:
In the field of cancer research, [(2R,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxo-hexoxy]phosphonic acid is used as a potential target for the development of anti-cancer drugs. Its involvement in the regulation of sialic acid production, which is often altered in cancer cells, makes it a valuable compound for investigating novel therapeutic strategies against cancer.
Used in Inflammation Research:
[(2R,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxo-hexoxy]phosphonic acid is also used in the research of anti-inflammatory drugs. Since sialic acids are known to play a role in immune response and inflammation, understanding the role of ManNAc-6P in their biosynthesis can lead to the development of new treatments for inflammatory conditions.
Used in Biochemical Research:
In the field of biochemical research, [(2R,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxo-hexoxy]phosphonic acid is utilized as a vital tool for studying the biosynthesis of sialic acids and their role in various biological processes. This knowledge can contribute to a better understanding of the underlying mechanisms of diseases and the development of targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1746-32-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,4 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1746-32:
(6*1)+(5*7)+(4*4)+(3*6)+(2*3)+(1*2)=83
83 % 10 = 3
So 1746-32-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5-,6-,7-,8+/m1/s1
1746-32-3Relevant articles and documents
Hydrophobic derivatives of 2-amino-2-deoxy-D-glucitol-6-phosphate: A new type of D-glucosamine-6-phosphate synthase inhibitors with antifungal action
Janiak, Agnieszka M.,Hoffmann, Maria,Milewska, Maria J.,Milewski, Slawomir
, p. 1653 - 1662 (2007/10/03)
Several N-acyl and ester derivatives of 2-amino-2-deoxy-D-glucitol-6-phosphate (ADGP) have been synthesised and tested as inhibitors of fungal enzymes involved in early steps of chitin biosynthesis and for antifungal activity. All the tested derivatives w
