174609-82-6

Basic information

• Product Name: 4-[(2-hydroxy-1-phenyl)ethyl]-1-(3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl)piperazine
• Synonyms: 4-[(2-hydroxy-1-phenyl)ethyl]-1-(3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl)piperazine
• CAS NO: 174609-82-6
• Molecular Weight: 430.553
• Mol File: 174609-82-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[(2-hydroxy-1-phenyl)ethyl]-1-(3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-hydroxy-1-phenyl)ethyl]-1-(3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl)piperazine(174609-82-6)
• EPA Substance Registry System: 4-[(2-hydroxy-1-phenyl)ethyl]-1-(3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl)piperazine(174609-82-6)

Safety Data

• Hazardous Substances Data: 174609-82-6(Hazardous Substances Data)

Upstream product

• 7757-82-6 sodium sulfate 
• 174609-57-5 5-[4-(tert-Butyloxycarbonyl)piperazin-1-yl]pentanal dimethyl acetal 
• 174609-58-6 1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]-4H-piperazine 
• 78643-42-2 5-bromopentanal dimethyl acetal 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 174609-79-1 (+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate 

Downstream Products

• 191033-05-3 1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]-4-[2-(oxazol-2-on-3-yl)-1-phenylethyl]piperazine 

Relevant articles and documents

3-(piperazinylpropyl)indoles: Selective, orally bioavailable h5-HT(1D) receptor agonists as potential antimigraine agents

Clinically effective antimigraine drugs such as Sumatriptan have similar affinity at h5-HT(1D) and h5-HT(1B) receptors. In the search for a h5- HT(1D)-selective agonist as an antimigraine agent, a novel series of 3- (propylpiperazinyl)indoles have been sy

Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists

Compounds of formula (I), or a salt or prodrug thereof, wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole; E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; Q represents a straight or branched alkylene chain containing from 1 to 6 carbon atoms, optionally substituted in any position by a hydroxy group; T represents nitrogen or CH; U represents nitrogen or C--R2 ; V represents oxygen, sulphur or N--R3 ; --F--G-- represents --CH2--N--, --CH2--CH-- or --CH=C--; R1 represents C3-6 alkenyl, C3-6 alkynyl, aryl(C1-6)alkyl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted; and R2 and R3 independently represent hydrogen or C1-6 alkyl are selective agonists of 5-HT1D receptors, being potent agonists of the human 5-HT1Dalpha receptor subtype, while possessing at least a 10-fold selective affinity for the 5-HT1Dalpha receptor subtype, relative to the 5-HT1Dbeta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, while eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.