174648-17-0

Basic information

• Product Name: 3-acetoxy-2,2-dimethoxypropyl dibenzyl phosphate
• Synonyms: 3-acetoxy-2,2-dimethoxypropyl dibenzyl phosphate
• CAS NO: 174648-17-0
• Molecular Weight: 438.414
• Mol File: 174648-17-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-acetoxy-2,2-dimethoxypropyl dibenzyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetoxy-2,2-dimethoxypropyl dibenzyl phosphate(174648-17-0)
• EPA Substance Registry System: 3-acetoxy-2,2-dimethoxypropyl dibenzyl phosphate(174648-17-0)

Safety Data

• Hazardous Substances Data: 174648-17-0(Hazardous Substances Data)

Upstream product

• 153214-82-5 2,2-dimethoxypropane-1,3-diol 
• 15205-57-9 tribenzyl phosphite 
• 36680-67-8 3-hydroxy-2,2-dimethoxypropyl acetate 
• 176506-97-1 dibenzyl phosphoroiodidate 
• 17176-77-1 Dibenzyl phosphite 

Downstream Products

• 29909-09-9 phosphoric acid mono-(3-hydroxy-2,2-dimethoxy-propyl ester) 
• 819862-89-0 3-hydroxy-2,2-dimethoxypropyl dibenzyl phosphate 

Relevant articles and documents

Improved straightforward chemical synthesis of dihydroxyacetone phosphate through enzymatic desymmetrization of 2,2-dimethoxypropane-1,3-diol

Dihydroxyacetone phosphate (DHAP) was synthesized in high purity and yield in four steps starting from dihydroxyacetone dimer (DHA) (47% overall yield). DHA was converted into 2,2-dimethoxypropane-1,3-diol, which was desymmetrized by acetylation with lipase AK. The alcohol function was phosphorylated to give dibenzyl phosphate ester 4. From 4, two routes were investigated for large-scale synthesis of DHAP. First, acetate hydrolysis was performed prior to hydrogenolysis of the phosphate protective groups. The acetal hydrolysis was finally catalyzed by the phosphate group itself. Second, acetate and acetal hydrolysis were performed in one single step after hydrogenolysis.