17473-74-4

Basic information

• Product Name: Benzoic acid,2-(4-methoxyphenyl)hydrazide
• Synonyms: Benzoicacid, 2-(p-methoxyphenyl)hydrazide (8CI); Benzoyl 2-(p-methoxyphenyl)hydrazide;NSC 98041
• CAS NO: 17473-74-4
• Molecular Formula: C14H14 N2 O2
• Molecular Weight: 242.277
• Mol File: 17473-74-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 353.8°Cat760mmHg
• Flash Point: 167.8°C
• Density: 1.204g/cm³
• CAS DataBase Reference: Benzoic acid,2-(4-methoxyphenyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid,2-(4-methoxyphenyl)hydrazide(17473-74-4)
• EPA Substance Registry System: Benzoic acid,2-(4-methoxyphenyl)hydrazide(17473-74-4)

Safety Data

• Hazardous Substances Data: 17473-74-4(Hazardous Substances Data)

Upstream product

• 93-97-0 benzoic acid anhydride 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 17333-79-8 p-methoxybenzenediazonium 
• 134-81-6 benzil 
• 98-88-4 benzoyl chloride 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 65-85-0 benzoic acid 
• 60636-95-5 2-(4-methoxyphenyl)-5-phenyltetrazole 
• 70-18-8 GLUTATHIONE 
• 56-86-0 L-glutamic acid 

Downstream Products

• 857816-29-6 N'-(4-methoxyphenyl)-N'-phenylbenzohydrazide 
• 143490-39-5 N',N'-bis(4-methoxyphenyl)benzohydrazide 
• 14572-15-7 N-benzoyl-N'-(4-methoxyphenyl)diazene 
• 60981-60-4 1-(chlorophenylmethylene)-2-(4-methoxyphenyl)hydrazine 
• 1426854-84-3 1-(4-methoxyphenyl)-1H-indazol-3-amine 

Relevant articles and documents

2-Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification

Photoaffinity labels are powerful tools for dissecting ligand-protein interactions, and they have a broad utility in medicinal chemistry and drug discovery. Traditional photoaffinity labels work through nonspecific C-H/X-H bond insertion reactions with th

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving “diversity with ease”, by combining classic C?C π-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels–Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates—demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.

Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase

Two series of diaza derivatives were prepared by solvent-free condensation of benzoic acid and 4-substituted phenylhydrazines in order to obtain phenylhydrazides (HYD series) and, by oxidation of these compounds, the corresponding benzoyldiazenes (DIA series). Both sets were evaluated as inhibitors of soybean 15-lipoxygenase activity and antioxidant capability in the FRAP and CUPRAC assays. The most potent inhibitors of both series exhibited IC50 values in the low micromolar range. Kinetic studies showed that at least the more active compounds were competitive inhibitors. Docking results indicated that the most potent inhibitor interacts strongly with Ile-839 and iron in the active site.