174819-21-7 Usage
Description
(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-1-<(4'-methoxyphenyl)methyl>-3,1-benzoxazin-2-one is a complex organic compound characterized by its unique molecular structure. It is a derivative of benzoxazinone, which is a heterocyclic compound with potential applications in various fields due to its chemical properties.
Uses
1. Used in Pharmaceutical Industry:
(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-1-<(4'-methoxyphenyl)methyl>-3,1-benzoxazin-2-one is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific targeting and therapeutic properties.
2. Used in the Synthesis of Efavirenz (E425000):
(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-1-<(4'-methoxyphenyl)methyl>-3,1-benzoxazin-2-one is used as a crucial component in the synthesis of Efavirenz, an HIV-1 reverse transcriptase inhibitor. This application highlights its importance in the development of antiretroviral medications, contributing to the fight against HIV/AIDS.
3. Used in Chemical Research:
Due to its complex structure and potential for modification, (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-1-<(4'-methoxyphenyl)methyl>-3,1-benzoxazin-2-one can be utilized in chemical research for the exploration of new reactions, mechanisms, and the development of novel synthetic methods.
4. Used in Material Science:
The unique properties of (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-1-<(4'-methoxyphenyl)methyl>-3,1-benzoxazin-2-one may also find applications in material science, where it could be used to develop new materials with specific properties, such as improved stability, reactivity, or selectivity in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 174819-21-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,8,1 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 174819-21:
(8*1)+(7*7)+(6*4)+(5*8)+(4*1)+(3*9)+(2*2)+(1*1)=157
157 % 10 = 7
So 174819-21-7 is a valid CAS Registry Number.
174819-21-7Relevant articles and documents
Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor
Pierce, Michael E.,Parsons Jr., Rodney L.,Radesca, Lilian A.,Lo, Young S.,Silverman, Stuart,Moore, James R.,Islam, Qamrul,Choudhury, Anusuya,Fortunak, Joseph M. D.,Nguyen, Dieu,Luo, Chi,Morgan, Susan J.,Davis, Wayne P.,Confalone, Pat N.,Chen, Cheng-Yi,Tillyer, Richard D.,Frey, Lisa,Tan, Lushi,Xu, Feng,Zhao, Dalian,Thompson, Andrew S.,Corley, Edward G.,Grabowski, Edward J. J.,Reamer, Robert,Reider, Paul J.
, p. 8536 - 8543 (2007/10/03)
A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) to p-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes the stereogenic center in the target with a remarkable level of stereocontrol.
