174890-58-5

Basic information

• Product Name: ethyl 2-(5-aMinopyridin-2-yl)acetate
• Synonyms: ethyl 2-(5-aMinopyridin-2-yl)acetate;Ethyl 5-aminopyridine-2-acetate
• CAS NO: 174890-58-5
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.20378
• Mol File: 174890-58-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 2-(5-aMinopyridin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(5-aMinopyridin-2-yl)acetate(174890-58-5)
• EPA Substance Registry System: ethyl 2-(5-aMinopyridin-2-yl)acetate(174890-58-5)

Safety Data

• Hazardous Substances Data: 174890-58-5(Hazardous Substances Data)

Usage

Description

Ethyl 2-(5-aMinopyridin-2-yl)acetate is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which features a pyridine ring and an ester functional group. This molecule is known for its potential applications in the development of drugs targeting specific receptors in the human body.

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(5-aMinopyridin-2-yl)acetate is used as a reactant in the synthetic preparation of phenethanolamine derivatives. These derivatives are known as β3-adrenoceptor agonists, which play a crucial role in the treatment of various medical conditions, such as obesity and type 2 diabetes. The compound's unique structure allows for the development of drugs that can effectively target and modulate the activity of β3-adrenoceptors, leading to improved therapeutic outcomes for patients.

Upstream product

• 415912-76-4 (5-amino-2-pyridinyl)acetic acid 
• 64-17-5 ethanol 
• 174890-57-4 ethyl 2-(5-nitropyridin-2-yl)acetate 
• 4548-45-2 2-chloro-5-nitropyridine 
• 921940-81-0 tert-butyl ethyl (5-nitropyridin-2-yl)malonate 
• 60891-70-5 1,3-diethyl 2-(5-nitropyridin-2-yl)propanedioate 

Downstream Products

• 921940-82-1 ethyl 2-(5-[[(tert-butoxy)carbonyl]amino]pyridin-2-yl)acetate 
• 1257342-98-5 5,7-dichloro-4-[(6-ethoxycarbonylmethyl-pyridin-3-ylcarbamoyl)-methoxy]-naphthalene-2-carboxylic methyl ester 

Relevant articles and documents

Making method of t-butyloxycarboryl-3-(hydroxymethyl)-[1,2,3]triazole[1,5-a]piperidine-6-amide

The invention relates to a synthesis method of t-butyloxycarboryl-3-(hydroxymethyl)-[1,2,3]triazole[1,5-a]piperidine-6-amide. The technical problem that a suitable industrial synthesis method does not exist at present is mainly solved. The synthesis method is divided into the following seven steps of firstly making (2-chloro-5-nitropyridine) and t-butyl ethyl malonate react in a solvent tetrahydrofuran under the action of NaH to obtain a compound 2; obtaining a compound 3 from the compound 2 under the action of trifluoroacetic acid; afterwards, subjecting the compound 3 to a hydrogenation reaction under the catalysis of palladium carbon to obtain a compound 4; carrying out t-butyloxycarboryl protection on the compound 4 to obtain a compound 5; making the compound 5 act with p-ABSA (p-Acetamidobenzenesulfonyl Azide) under the action of DBU (1,8-Diazabicyclo[5,4,0]undec-7-ene) to obtain a compound 6; reducing the compound 6 in the tetrahydrofuran by lithium aluminium tetrahydride to obtain a compound 7; subjecting the compound 7 to catalytic hydrogenation under the catalysis of wet palladium carbon to obtain a final compound 8.

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