174905-89-6

Basic information

• Product Name: (2R-trans)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine
• Synonyms: (2R-trans)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine
• CAS NO: 174905-89-6
• Molecular Weight: 486.632
• Mol File: 174905-89-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R-trans)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R-trans)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine(174905-89-6)
• EPA Substance Registry System: (2R-trans)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine(174905-89-6)

Safety Data

• Hazardous Substances Data: 174905-89-6(Hazardous Substances Data)

Upstream product

• 109838-85-9 (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine 
• 174905-86-3 1-(chloromethyl)-3,5-dimethoxy-2-{[(4-methoxyphenyl)methyl]thio}benzene 
• 174905-84-1 N,N-diethyl-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>benzenemethanamine 
• 174905-82-9 N,N-diethyl-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>benzamide 
• 824-94-2 p-methoxybenzyl chloride 
• 38228-27-2 N,N-diethyl-3,5-dimethoxybenzamide 

Downstream Products

• 174905-91-0 3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester 

Relevant articles and documents

Syntheses of 1-phenylalanine derivatives containing a sulfur substituent at the 2-position

A full account is given of the chiral syntheses of sulfur-containing L-phenylalanine derivatives (8b,c), selected as key intermediates for the synthesis of models for the starfish alkaloid imbricatine (7), via a 5-step route starting from N,N-diethyl-3,5-dimethoxybenzamide (9). The key steps involve introduction of a sulfur substituent into 9 at the 2-position and construction of the chiral α-amino acid moiety in the chlorides (12b,c) by the "bis-lactim ether" method.