175090-76-3

Basic information

• Product Name: N-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)succinamic acid methyl ester
• Synonyms: PP1D-1
• CAS NO: 175090-76-3
• Molecular Formula: C₁₅H₁₂ClNO₅
• Molecular Weight: 321.71959
• Mol File: 175090-76-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)succinamic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)succinamic acid methyl ester(175090-76-3)
• EPA Substance Registry System: N-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)succinamic acid methyl ester(175090-76-3)

Safety Data

• Hazardous Substances Data: 175090-76-3(Hazardous Substances Data)

Upstream product

• 2797-51-5 quinoclamine 
• 1490-25-1 succinic acid monomethylester chloride 

Downstream Products

• 175090-57-0 N-(1,4-Dioxo-3-phenylamino-1,4-dihydro-naphthalen-2-yl)-succinamic acid methyl ester 
• 175090-58-1 N-(3-Benzylamino-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-succinamic acid methyl ester 

Relevant articles and documents

Synthesis of 2,3-disubstituted 1,4-naphthoquinones as antiplatelet agents

In continuing search for novel antiplatelet agents, the highly potent agent 2-chloro-3-methoxycarbonylethylcarboxamido-1,4-naphthoquinone 2 was selected as lead compound. Structureactivity relationships in this series were examined. Some of these compound

Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds

As part of our continuing search for potential anticancer drug candidates that are selective against slowly growing solid tumors, we have synthesized several series of 1- and 2-substituted derivatives of the lead structure, 1-ethyl-2-methylnaphth[2,3-d]midazole-4,9-dione (5). Their cytotoxic activity in the National Cancer Institute's in vitro cancer cell line panel is reported. In general, substitution of various alkyl, phenyl, or benzyl moieties did not improve activity, and compound 5 remains the most active naphth[2,3-d]imidazole-4,9-dione derivative. However, high levels of activity and selectivity were found with several related 2-(acylamino)-3-chloro1,4-naphthoquinones (2f-j). Compound 2i, 2-[(2-fluorophenyl)acetamido]-3-chloro-1,4-naphthoquinone, has been selected for further in vivo testing and as an additional lead compound for further structural modification.