175137-21-0

Basic information

• Product Name: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE
• Synonyms: BUTTPARK 46\18-89;4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE;4-Chloro-7-methylthieno[2,3-d]pyrimidine;7-CHLORO-3-METHYLTHIENO(3,2-D)PYRIMIDINE;4-Chloro-7-methylthieno[3,2-d]pyrimidine 97%;4-Chloro-7-Methylthieno[3...;4-Chloro-7-methylthieno[3,2-d]pyrimidine97%
• CAS NO: 175137-21-0
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.65
• Mol File: 175137-21-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124 °C
• Boiling Point: 301.3°C at 760 mmHg
• Flash Point: 136°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 0.0019mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.78±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE(175137-21-0)
• EPA Substance Registry System: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE(175137-21-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 175137-21-0(Hazardous Substances Data)

Usage

General Description

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE is a chemical compound with the molecular formula C6H5ClN2S. It is a heterocyclic organic compound that contains a chlorine atom and a methyl group attached to a thiophene ring, and a pyrimidine ring. 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE is mainly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and biologically active molecules. It is also used in the research and development of new drugs and agrochemicals. 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE is also used as a building block in organic synthesis for the preparation of various organic compounds.

InChI:InChI=1/C7H5ClN2S/c1-4-2-11-6-5(4)9-3-10-7(6)8/h2-3H,1H3

Upstream product

• 175137-13-0 7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one 
• 443762-03-6 methyl 3-formamido-4-methylthiophene-2-carboxylate 
• 1246223-39-1 C₈H₈N₂S₂ 
• 85006-31-1 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 18678-13-2 2-methylthieno[3,2-d]pyrimidin-4-ol 

Downstream Products

• 1017606-57-3 C₂₁H₂₇N₅S 
• 209286-57-7 7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine 
• 1269667-57-3 4-chlorothieno[3,2-d]pyrimidine-7-carboxylic acid 
• 1318133-05-9 4-chloro-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318133-07-1 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318128-97-0 4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318133-08-2 N-(4-bromo-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide 
• 1318130-12-9 N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide 
• 1318131-14-4 N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318241-64-3 4-(cyclopropylamino)-N-(2-methyl-5-(3-(2-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)phenylcarbamoyl)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318241-82-5 4-(cyclopropylamino)-N-(2-methyl-5-(4-morpholino-3-(trifluoromethyl)benzamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318243-02-5 t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate 
• 1318243-03-6 N-(5-amino-2-methylphenyl)-4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamide 
• 871013-26-2 7-methylthieno[3,2-d]pyrimidine 

Relevant articles and documents

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF

Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

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A novel thienopyrimidinone analog was discovered as a potent and highly selective TAK1 inhibitor using the SBDD approach. TAK1 plays a key role in inflammatory and immune signaling, so TAK1 is considered to be an attractive molecular target for the treatm

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.