175140-70-2Relevant articles and documents
Corticotropin releasing factor antagonists
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, (2008/06/13)
Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes fo
Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists
Beck, James P.,Arvanitis, Argyrios G.,Curry, Matt A.,Rescinito, Joseph T.,Fitzgerald, Larry W.,Gilligan, Paul J.,Zaczek, Robert,Trainor, George L.
, p. 967 - 972 (2007/10/03)
A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.