175203-54-0

Basic information

• Product Name: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE
• Synonyms: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE;2-ACETYL-5-(PHENYLETHYNYL)THIOPHENE;1-[5-(2-phenylethynyl)thiophen-2-yl]ethan-1-one
• CAS NO: 175203-54-0
• Molecular Formula: C14H10OS
• Molecular Weight: 226.29
• Mol File: 175203-54-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 403.2°Cat760mmHg
• Flash Point: 197.6°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE(175203-54-0)
• EPA Substance Registry System: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE(175203-54-0)

Safety Data

• Hazardous Substances Data: 175203-54-0(Hazardous Substances Data)

Usage

General Description

1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE is a chemical compound with a molecular formula of C16H12OS. It is a member of the ketone class of organic compounds and contains a thienyl and phenylethynyl group. 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE is primarily used in research and scientific studies, particularly in the field of organic chemistry and drug development. Its properties and potential applications are still under investigation, and it may have potential uses in pharmaceutical and medicinal chemistry due to its unique structure and potential reactivity. Additional research is needed to fully understand the properties and potential applications of this chemical compound.

InChI:InChI=1/C14H10OS/c1-11(15)14-10-9-13(16-14)8-7-12-5-3-2-4-6-12/h2-6,9-10H,1H3

Upstream product

• 5370-25-2 2-Acetyl-5-bromothiophene 
• 637-44-5 phenylpropyolic acid 
• 206551-43-1 (5-acetylthiophen-2-yl)boronic acid 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 88-15-3 2-Acetylthiophene 
• 536-74-3 phenylacetylene 

Downstream Products

• 317334-25-1 1-(1H-Imidazol-2-yl)-3-(5-phenethyl-thiophen-2-yl)propane-1,3-dione trifluoroacetate 
• 317335-11-8 3-hydroxy-3-(1H-imidazol-2-yl)-1-(5-phenethylthiophen-2-yl)propan-1-one 
• 317335-10-7 3-hydroxy-1-(5-phenethylthiophen-2-yl)-3-(1-trityl-1H-imidazol-2-yl)propan-1-one 

Relevant articles and documents

Alkynylboranes: A practical approach by zinc-catalyzed dehydrogenative coupling of terminal alkynes with 1,8-naphthalenediaminatoborane

Under zinc Lewis acid catalysis, terminal alkynes coupled dehydrogenatively with 1,8-naphthalenediaminatoborane [HB(dan)]. It is important to note that the resulting alkynylboranes with an C(sp) - B(dan) bond are isolable by column chromatography on silica gel (SiO2) and are usable as coupling partners for palladium- and copper-catalyzed cross-coupling reactions with (hetero)aryl halides.

Mild Pd/Cu-catalyzed sila-sonogashira coupling of (hetero)aryl bromides with (hetero)arylethynylsilanes under PTC conditions

The palladium/copper cocatalyzed sila-Sonogashira reaction of (hetero)arylethynysilanes with (hetero)aryl bromides in toluene and water at 40 C under PTC conditions gave the required di(hetero)arylethynes in moderate to high yields. Activated, deactivated and ortho-substituted (hetero)aryl bromides are well tolerated. This protocol also allowed the preparation of symmetrical diarylethynes by double arylation of 1,2-bis(trimethylsilyl)ethyne. Georg Thieme Verlag Stuttgart · New York.

Palladhim-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide

Palladium-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide have been developed. A variety of α,β-ynoic acids were readily decarboxylated in the presence of