175272-36-3

Basic information

• Product Name: 2-Oxazolidinone, 3-[(2S)-2-methyl-1-oxo-4-pentenyl]-4-(phenylmethyl)-, (4R)-
• CAS NO: 175272-36-3
• Molecular Formula: C16H19NO3
• Molecular Weight: 273.332
• Mol File: 175272-36-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-[(2S)-2-methyl-1-oxo-4-pentenyl]-4-(phenylmethyl)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-[(2S)-2-methyl-1-oxo-4-pentenyl]-4-(phenylmethyl)-, (4R)-(175272-36-3)
• EPA Substance Registry System: 2-Oxazolidinone, 3-[(2S)-2-methyl-1-oxo-4-pentenyl]-4-(phenylmethyl)-, (4R)-(175272-36-3)

Safety Data

• Hazardous Substances Data: 175272-36-3(Hazardous Substances Data)

Upstream product

• 24850-33-7 allyltributylstanane 
• 556-56-9 allyl iodid 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 18854-63-2 allylmagnesium iodide 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 106-95-6 allyl bromide 

Downstream Products

• 5673-98-3 (S)-(-)-2-methyl-4-penten-1-ol 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 503620-07-3 4-benzyl-3-{2-methyl-6-[3-methyl-5-(2-trimethylsilanyl-ethoxy)-tetrahydro-furan-2-yl]-hex-4-enoyl}-oxazolidin-2-one 
• 444177-89-3 (R)-4-Benzyl-3-((S)-5-hydroxy-2-methyl-pentanoyl)-oxazolidin-2-one 
• 147649-95-4 (S)-2-Methyl-4-pentenoic acid phenylmethyl ester 
• 439217-33-1 2,2-Dimethyl-propionic acid (2S,4S)-4-benzyloxy-5-hydroxy-2-methyl-pentyl ester 
• 439217-29-5 (2S,4S)-4-Benzyloxy-2-methyl-5-triethylsilanyloxy-pentanal 
• 439217-34-2 (2S,4S)-4-Benzyloxy-2-methyl-5-triethylsilanyloxy-pentan-1-ol 
• 439217-28-4 2,2-Dimethyl-propionic acid (2S,4S)-4-benzyloxy-2-methyl-5-triethylsilanyloxy-pentyl ester 
• 439217-27-3 2,2-Dimethyl-propionic acid (2S,4S)-4-benzyloxy-2-methyl-5-triisopropylsilanyloxy-pentyl ester 
• 444177-92-8 (R)-4-Benzyl-3-((S)-2-methyl-5-triethylsilanyloxy-pentanoyl)-oxazolidin-2-one 
• 444177-88-2 tert-Butyl-[(E)-5-((2S,6R,8S,13S)-13-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-4-en-2-yl)-pent-4-enyloxy]-diphenyl-silane 
• 439217-19-3 [(E)-5-((2S,6R,8S,11S,13S)-11-Benzyloxy-13-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-4-en-2-yl)-pent-4-enyloxy]-tert-butyl-diphenyl-silane 
• 439217-18-2 [(E)-5-((2S,6R,8R,11S,13S)-11-Benzyloxy-13-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-4-en-2-yl)-pent-4-enyloxy]-tert-butyl-diphenyl-silane 

Relevant articles and documents

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ22 steroids

A synthetic route that utilizes a cross-metathesis reaction with Δ22 steroids has been developed to prepare sterols with varying C-27 side-chains. Natural sterols containing hydroxyl groups at the 25 and (25R)-26 positions were prepared. Enantiomers of cholesterol and (3β,25R)-26-hydroxycholesterol (27-hydroxycholesterol) trideuterated at C-19 were prepared for future biological studies.

MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.