175278-09-8

Basic information

• Product Name: 4-Bromo-2-trifluoromethoxyaniline
• Synonyms: 2-AMINO-5-BROMO TRIFLUOROMETHOXY BENZENE;4-BROMO-2-(TRIFLUOROMETHOXY)ANILINE;BUTTPARK 50\01-74;TIMTEC-BB SBB005835;4-bromo-2-(trifluoromrthoxy)aniline;4-Bromo-2-(trifluoromethoxy)aniline 98%;4-Bromo-2-(trifluoromethoxy)aniline98%;4-Bromo-2-trifluoromethoxy-phenylamine
• CAS NO: 175278-09-8
• Molecular Formula: C₇H₅BrF₃NO
• Molecular Weight: 256.02
• Product Categories: Trifluoroanisole series;Anilines, Aromatic Amines and Nitro Compounds;Amines;C7;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Fluorine series
• Mol File: 175278-09-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 98-100 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: clear pale yellow to orange-yellow liquid
• Density: 1.691 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.205mmHg at 25°C
• Refractive Index: n20/D 1.5130(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.75±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-2-trifluoromethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-trifluoromethoxyaniline(175278-09-8)
• EPA Substance Registry System: 4-Bromo-2-trifluoromethoxyaniline(175278-09-8)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-43-52/53-36/37/38
• Safety Statements: 36/37-45-37/39-26
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 2
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 175278-09-8(Hazardous Substances Data)

Usage

Chemical Properties

clear pale yellow to orange-yellow liquid

InChI:InChI=1/C7H5BrF3NO/c8-4-1-2-5(12)6(3-4)13-7(9,10)11/h1-3H,12H2

Upstream product

• 1535-75-7 2-trifluoromethoxy aniline 

Downstream Products

• 406232-79-9 4-bromo-1-chloro-2-(trifluoromethyloxy)benzene 
• 2252-44-0 1-bromo-3-(trifluoromethoxy)benzene 
• 1034732-96-1 4-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 
• 1352342-47-2 C₁₅H₁₅BrF₃NO₅ 
• 1386950-85-1 N,N-dibenzyl-4-bromo-2-(trifluoromethoxy)aniline 
• 1386950-86-2 tert-butyl 4-(4-(dibenzylamino)-3-(trifluoromethoxy)phenyl)piperazine-1-carboxylate 
• 1374641-77-6 tert-butyl 4-(4-amino-3-trifluoromethoxyphenyl)piperazine-1-carboxylate 
• 1489391-85-6 C₇H₃BrF₃N₂O⁽¹⁺⁾ 
• 1489176-06-8 C₁₂H₆BrF₃O₃ 
• 1489176-75-1 C₂₂H₁₅BrClF₃N₄O₄*ClH 
• 1577131-71-5 (E)-2-(((4-bromo-2-(trifluoromethoxy)phenyl)imino)methyl)-4-nitrophenol 
• 457097-93-7 4-amino-3-trifluoromethoxybenzoic acid methyl ester 
• 1261444-00-1 methyl 4-chloro-3-(trifluoromethoxy)benzoate 
• 886500-50-1 4-chloro-3-(trifluoromethoxy)benzoic acid 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

PROCESS FOR THE PREPARATION OF 1-BROMO-3-TRIFLUOROMETHOXYBENZENE

The invention concerns a process for the preparation of 1-bromo-3- trifluoromethoxybenzene starting from 2- or 4-trifluoromethoxyaniline or a mixture of these compounds via a synthesis that provides excellent yields and surprising selectivity.