175278-17-8

Basic information

• Product Name: 2-Bromo-4-trifluoromethoxyaniline
• Synonyms: 2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE;BUTTPARK 83\07-26;2-Bromo-4-(trifluoromethoxy)aniline 98%;2-Bromo-4-(trifluoromethoxy)aniline98%;2-Bromo-4-(trifluoeomethoxy)aniline;2-Bromo-4-trifluorom
• CAS NO: 175278-17-8
• Molecular Formula: C₇H₅BrF₃NO
• Molecular Weight: 256.02
• Product Categories: blocks;Bromides;FluoroCompounds;NitroCompounds;Anilines, Aromatic Amines and Nitro Compounds;Amines;C7;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Fluorine series;amine| alkyl bromide
• Mol File: 175278-17-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 209 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear light yellow to orange-yellow/Liquid
• Density: 1.693 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000993mmHg at 25°C
• Refractive Index: n20/D 1.504(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.68±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-trifluoromethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-trifluoromethoxyaniline(175278-17-8)
• EPA Substance Registry System: 2-Bromo-4-trifluoromethoxyaniline(175278-17-8)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 175278-17-8(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow to orange-yellow liquid

InChI:InChI=1/C9H7BrF3NO2/c1-5(15)14-7-3-2-6(10)4-8(7)16-9(11,12)13/h2-4H,1H3,(H,14,15)

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 88149-49-9 2,6-dibromo-4-(trifluoromethoxy)aniline 
• 123-30-8 4-amino-phenol 

Downstream Products

• 220953-23-1 6-(2-bromo-4-trifluoromethoxy-phenylamino)-2-methyl-5-nitro-3H-pyrimidin-4-one 
• 852102-05-7 N-{2-bromo-4-[(trifluoromethyl)oxy]phenyl}-2,2-diethylbut-3-enamide 
• 875143-35-4 2-bromo-4-trifluoromethoxythiophenol 
• 932700-84-0 1,1-dimethylethyl 4-{[({2-bromo-4-[(trifluoromethyl)oxy]phenyl}amino)carbonyl]amino}-1-piperidinecarboxylate 
• 955043-77-3 N-(2-bromo-4-(trifluoromethoxy)phenyl)-2-naphthamide 
• 220953-28-6 (2-bromo-4-trifluoromethoxy-phenyl)-(6-chloro-2-methyl-5-nitro-pyrimidin-4-yl)-amine 
• 1027222-06-5 N-(2-bromo-4-trifluoromethoxy-phenyl)-N'',N''-bis-(2-methoxy-ethyl)-2-methyl-pyrimidine-4,5,6-triamine 

Relevant articles and documents

Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)

The method disclosed by the invention 4 - is characterized in that the aminophenol, and the alkali :(1) are reacted at a mole ratio of the 1:0.8-1.5, 20-40 °C compound 0.1-24h with the halogen, and, the halogen compound in the solvent to 1:1.0-3.0,20-120 °C, 0.01-20Mpa react with 1-72h. 1-72h the 4 - 1:0.8-30.0 ammonia solution ;(2)4 - or the halogen compound at a mole ratio of the compound of the 1:0.2 - 2.5 amino phenol, 30-80 °C with 0.1-24h;(3)4 - the halogen and the halogen compound in the solvent 0.1-10%, 50-200 °C, 0.01-10Mpa: 4 . (by machine translation)

Direct Tryptophols Synthesis from 2-Vinylanilines and Alkynes via C - C Triple Bond Cleavage and Dioxygen Activation

An unexpected metal-free C - C triple bond cleavage, dioxygen activation, and reassembly into tryptophol derivatives has been developed. This chemistry provides a novel, simple, and efficient approach to highly valuable tryptophol derivatives from simple substrates under mild conditions. The mechanistic studies may promote the discovery of new methodologies through C-C bond cleavage and dioxygen activation.

Catalytic asymmetric pictet-spengler-type reaction for the synthesis of optically active indolo[3,4-cd][1]benzazepines

A new strategy has been introduced to develop a catalytic asymmetric Pictet-Spengler-type reaction by replacing the aldehyde with an imine. A range of 4-(2-aminoaryl)indoles smoothly undergo the chiral phosphoric acid catalyzed asymmetric Pictet-Spengler-