175291-56-2 Usage
Description
Fmoc-O-(benzylphospho)-L-threonine is a synthetic peptide building block that is primarily used in the synthesis of phosphothreonine-containing peptides and macrocyclic peptidomimetics. It is a white to off-white powder and has gained significant attention in the field of pharmaceuticals and biochemistry due to its potential applications.
Uses
1. Used in Pharmaceutical Industry:
Fmoc-O-(benzylphospho)-L-threonine is used as a building block for the synthesis of phosphothreonine-containing peptides, which are essential components in various biological processes and have potential therapeutic applications.
2. Used in Biochemical Research:
Fmoc-O-(benzylphospho)-L-threonine is used as a synthetic peptide in the synthesis of macrocyclic peptidomimetics, specifically as polo-like kinase 1 polo-box domain-binding inhibitors. These inhibitors play a crucial role in understanding the structure and function of protein-protein interactions and can be used to develop targeted therapies for various diseases.
3. Used in Chemical Synthesis:
Fmoc-O-(benzylphospho)-L-threonine is used as a key intermediate in the synthesis of complex peptides and peptidomimetics, contributing to the development of novel bioactive molecules with potential applications in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 175291-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,9 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 175291-56:
(8*1)+(7*7)+(6*5)+(5*2)+(4*9)+(3*1)+(2*5)+(1*6)=152
152 % 10 = 2
So 175291-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C26H26NO8P/c1-17(35-36(31,32)34-15-18-9-3-2-4-10-18)24(25(28)29)27-26(30)33-16-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h2-14,17,23-24H,15-16H2,1H3,(H,27,30)(H,28,29)(H,31,32)/t17-,24+/m0/s1
175291-56-2Relevant articles and documents
PROCESS FOR PREPARING PHOSPHORYLATED AMINO ACIDS
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Page/Page column 78; 82, (2013/03/26)
The present invention provides a short, safe, inexpensive, commercially scalable process for preparing a phosphorylated amino acid of Formula I, which can be performed in one pot without isolating any synthetic intermediates.
A general preparation of protected phosphoamino acids
Petrillo, Daniel E.,Mowrey, Dale R.,Allwein, Shawn P.,Bakale, Roger P.
, p. 1206 - 1209 (2012/05/04)
Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
