175354-96-8

Basic information

• Product Name: 5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine
• Synonyms: 5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine
• CAS NO: 175354-96-8
• Molecular Weight: 490.634
• Mol File: 175354-96-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine(175354-96-8)
• EPA Substance Registry System: 5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine(175354-96-8)

Safety Data

• Hazardous Substances Data: 175354-96-8(Hazardous Substances Data)

Upstream product

• 890-38-0 2-deoxyinosine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1054645-74-7 Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester 
• 1054682-46-0 Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester 

Relevant articles and documents

A simple synthesis of 2-deoxy-3-thioinosine and its phosphorothioamidite

5-O-{[Bis(4-methoxyphenyl)(phenyl)methyl])-2-deoxy-3-thioinosine and its S-phosphorothioamidite were prepared in five and six steps, respectively, from commercially available 2-deoxyinosine. The key 3-thio intermediate was synthesized by two sequential configuration inversions: a one-pot oxidation/reduction reaction and an S reaction. This intermediate was readily converted into the target compound with a high yield. Compared with other methods, this synthetic strategy has the advantages of brief reaction steps, a relatively high overall yield, and regioselectivity for the configuration inversions. The products might be useful as intermediates for the preparation of new functionalized nucleosides. Georg Thieme Verlag Stuttgart · New York.