175476-13-8Relevant articles and documents
PREPARATION OF 1-HYDROXYXANTHEN-9(9H)-ONES AND 1-HYDROXYACRIDIN-9(10H)-ONES VIA CORRESPONDING 3,4-DIHYDRO-1,9(2H)-DIONES
Radl, Stanislav
, p. 2127 - 2136 (2007/10/03)
Target 10-cyclopropyl-7-fluoro-6-(4-methyl-1-piperazinyl)acridin-9(10H)-one (IVc) and 7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)-9H-xanthen-9-one (IVd) were obtained from corresponding difluoro derivatives IVa and IVb, respectively.These intermediates were synthesized via respective 3,4-dihydro-1,9(2H)-diones Va and Vb.Acridine derivative (10-cyclopropyl-6,7-difluoro-3,4-dihydro-1H-acridine-1,9(2H,10H)-dione, Va) was synthesized from 1-cyclopropyl-6,7-difluoroisatoic anhydride (XI) and xanthene derivative (6,7-difluoro-3,4-dihydro-1H-xanthen-1,9(2H)-dione, Vb) from cyclohexenone derivative VIb.Several unsuccessful attempts to prepare hydroxyacridone IVc and/or some useful intermediates of its synthesis are also described.