175692-25-8

Basic information

• Product Name: N¹-(2-Benzhydryloxy-ethyl)-N¹-methyl-heptane-1,7-diamine
• Synonyms: N¹-(2-Benzhydryloxy-ethyl)-N¹-methyl-heptane-1,7-diamine
• CAS NO: 175692-25-8
• Molecular Weight: 354.536
• Mol File: 175692-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N¹-(2-Benzhydryloxy-ethyl)-N¹-methyl-heptane-1,7-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-(2-Benzhydryloxy-ethyl)-N¹-methyl-heptane-1,7-diamine(175692-25-8)
• EPA Substance Registry System: N¹-(2-Benzhydryloxy-ethyl)-N¹-methyl-heptane-1,7-diamine(175692-25-8)

Safety Data

• Hazardous Substances Data: 175692-25-8(Hazardous Substances Data)

Upstream product

• 17471-10-2 Desmethyldiphenhydramine 
• 58-73-1 2-diphenylmethoxy-N,N-dimethylethanamine 
• 20965-27-9 7-bromo-heptanonitrile 
• 175692-19-0 7-[(2-Benzhydryloxy-ethyl)-methyl-amino]-heptanenitrile 

Relevant articles and documents

Synthesis and pharmacology of combined histamine H1-/H2-receptor antagonists containing diphenhydramine and cyproheptadine derivatives

The classical histamine H1-receptor antagonists diphenhydramine (3a) and cyproheptadine (9) and their derivatives (3b-d, 10) were connected with a 2-guanidinothiazole containing structure (28) derived from the H2-receptor antagonist tiotidine in order to obtain combined H1/H2-receptor antagonists. The two moieties were not directly linked together, but were separated by a polymethylene spacer and a polar group (nitroethenediamine or urea). Thus 12 compounds were obtained that proved in vitro to possess high H1- and H2-receptor antagonist activity at the isolated guinea-pig ileum (H1) and the isolated guinea-pig right atrium (H2), respectively. The incorporation of the diphenhydramine as well as the cyproheptadine component provides high affinity to H1-receptors. The tricyclic cyproheptadine and its 10,11-dihydro derivative (30-32, 34), however, cause a decrease of H2-receptor antagonist potency compared to the diphenhydramines (29a-d, 33a-d). Using nitroethenediamine as the polar group is apparently more favourable to H1- and H2-receptor affinity as the urea function. All compounds elicit a dual mode of competitive and noncompetitive antagonism. Among the novel compounds the nitroethenediamines with 4-fluoro- or 4-methyl-substituted diphenhydramine as H1-receptor antagonist moiety (29c, d) display the most potent H1- and H2-receptor antagonist effects. The presented concept is a very promising way to combine H1- and H2-receptor antagonist properties in one molecule.