17573-78-3

Basic information

• Product Name: 4,5,6-TRIFLUOROPYRIMIDINE
• Synonyms: 4,5,6-TRIFLUOROPYRIMIDINE;Pyrimidine, 4,5,6-trifluoro- (8CI,9CI);4,5,6-Trifluoro-1,3-diazine;Pyrimidine,4,5,6-trifluoro-
• CAS NO: 17573-78-3
• Molecular Formula: C₄HF₃N₂
• Molecular Weight: 134.06
• Product Categories: PYRIMIDINE;PyrimidinesBuilding Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;Pyrroles
• Mol File: 17573-78-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 83-85°C
• Flash Point: 83-85°C
• Appearance: /
• Density: 1.4609
• Vapor Pressure: 9.56mmHg at 25°C
• Refractive Index: 1.4087
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetone, Chloroform, Methanol (Slightly)
• PKA: -6.10±0.26(Predicted)
• CAS DataBase Reference: 4,5,6-TRIFLUOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6-TRIFLUOROPYRIMIDINE(17573-78-3)
• EPA Substance Registry System: 4,5,6-TRIFLUOROPYRIMIDINE(17573-78-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 17573-78-3(Hazardous Substances Data)

Usage

Description

4,5,6-Trifluoropyrimidine is a chemical compound characterized by the presence of three fluorine atoms at the 4th, 5th, and 6th positions of the pyrimidine ring. It is a synthetic molecule with potential applications in various fields, particularly in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
4,5,6-Trifluoropyrimidine is used as a starting material for the preparation of O-linked pyrimidinamine-based compounds. These compounds serve as deoxycytidine kinase inhibitors, which are crucial in the treatment of cancer. By inhibiting the activity of deoxycytidine kinase, these compounds can disrupt the synthesis of DNA and RNA in cancer cells, thereby hindering their growth and proliferation. This makes 4,5,6-trifluoropyrimidine a valuable component in the development of novel anticancer drugs.

InChI:InChI=1/C4HF3N2/c5-2-3(6)8-1-9-4(2)7/h1H

Upstream product

• 25096-66-6 5-chloro-4,6-difluoro-pyrimidine 
• 1780-27-4 4,5,6-trichloropyrimidine 
• 2751-90-8 tetraphenylphosphonium bromide 

Downstream Products

• 308286-27-3 N-methyl-(E)-2-[2-(5,6-difluoro-pyrimidin-4-yloxy)-phenyl]-2-methoxyiminoacetamide 
• 313229-48-0 4-(3-fluorophenoxy)-5,6-difluoropyrimidine 
• 164791-85-9 methyl 2-[2-(5,6-difluoro-4-pyrimidinyloxy)-phenyl]-3-methyloxy-acrylate 
• 220518-06-9 3-{1-[2-(4,5-difluoropyrimid-6-yloxy)-phenyl]-1-(methoximino)-methyl}-5,6-dihydro-4H-1,2,4-oxadiazine 
• 308286-28-4 N-methyl-(Z)-2-[2-(5,6-difluoro-pyrimidin-4-yloxy)-phenyl]-2-methoxyiminoacetamide 

Relevant articles and documents

POTASSIUM FLUORIDE DISPERSION SOLUTION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME

A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion.

Halogen pyrimidinyl aryl (thio) ethers as pesticides

The invention relates to novel halogenopyrimidines, to two processes for their preparation and to their use as pesticides.

Halogen pyrimidinyl aryl (thio)ethers as pesticides

The invention relates to novel halogenopyrimidines, to two processes for their preparation and to their use as pesticides.