175739-42-1

Basic information

• Product Name: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 175739-42-1
• Molecular Formula: C₂₂H₂₄N₂O₃
• Molecular Weight: 364.4376
• Mol File: 175739-42-1.mol
• Article Data: 3

Chemical Properties

• Density: 1.172g/cm³
• Refractive Index: 1.582
• CAS DataBase Reference: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione(175739-42-1)
• EPA Substance Registry System: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione(175739-42-1)

Safety Data

• Hazardous Substances Data: 175739-42-1(Hazardous Substances Data)

Usage

General Description

6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione, also known as BzPMPD, is a chemical compound that belongs to the class of pyrimidine derivatives. It contains a benzyl group, a benzyloxy group, and a propan-2-yl group attached to the pyrimidine ring. BzPMPD has been studied for its potential pharmacological activities, including its anti-inflammatory and anti-hypertensive properties. It has also been researched for its potential use as a precursor in the development of new pharmaceutical drugs. The chemical structure and properties of BzPMPD make it an interesting target for further investigation in the field of medicinal chemistry.

Upstream product

• 609-12-1 ethyl 2-bromoisovalerate 
• 3587-60-8 Benzyloxymethyl chloride 
• 176519-55-4 6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione 
• 176519-53-2 ethyl 2-isopropyl-3-oxo-4-phenylbutanoate 
• 140-29-4 phenylacetonitrile 
• 100-51-6 benzyl alcohol 
• 199851-91-7 6-benzyl-5-isopropyl-2-thiouracil 
• 103-80-0 phenylacetyl chloride 
• 718-08-1 ethyl 3-oxo-4-phenylbutyrate 

Relevant articles and documents

New efficient and flexible synthetic route to Emivirine and its analogs

A revised synthetic route to Emivirine (MKC-442) via properly substituted β-keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC-442 analogues and open the way for their systematic biological evaluation.

N-3 hydroxylation of pyrimidine-2,4-diones yields dual inhibitors of HIV reverse transcriptase and integrase

A new molecular scaffold featuring an N-hydroxyimide functionality and capable of inhibiting both reverse transcriptase (RT) and integrase (IN) of human immunodeficiency virus (HIV) was rationally designed based on 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) non-nucleoside RT inhibitors (NNRTIs). The design involves a minimal 3-N hydroxylation of the pyrimidine ring of HEPT compound to yield a chelating triad which, along with the existing benzyl group, appeared to satisfy major structural requirements for IN binding. In the mean time, this chemical modification did not severely compromise the compound's ability to inhibit RT. A preliminary structure-activity relationship (SAR) study reveals that this N-3 OH is essential for IN inhibition and that the benzyl group on N-1 side chain is more important for IN binding than the one on C-6.