175857-65-5Relevant articles and documents
A new synthetic route to 2-alkyl-4-aryl-1(2H)-isoquinolones and 2-alkyl-4-aryl-1,2,3,4-tetrahydroisoquinolines
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Woisel, Patrice
, p. 4433 - 4448 (1996)
4-Aryl and heteroaryl-1(2H)-isoquinolones have been prepared by base promoted cyclization of phosphorylated o-aroyl and heteroaroyl benzamides. Subsequent reduction of the carbonyl and styryl functions of the annulated products has given rise to 4-aryl-1,2,3,4-tetrahydroisoquinolines.
First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Lebrun, Stephane,Leonce, Stephane,Renard, Pierre,Pfeiffer, Bruno
, p. 2113 - 2125 (2007/10/03)
The benzoindolizidine and-quinolizidine analogues of α- and β-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. Copyright (C) 2000 Elsevier Science Ltd.
Dramatically different photochemical behaviour of 1-aroyl-2-methylene piperidine and pyrrolidine derivatives. An expeditious synthesis of ruspolinone
Couture,Deniau,Grandclaudon,Lebrun
, p. 7749 - 7752 (2007/10/03)
Upon irradiation in neutral solvent, the diversely substituted 1-aroyl-2-methylenepiperidines 6a-f give rise to photocyclized products 4a-f while their pyrrolidine congeners 7a,c,d afford enaminoketones 18a,c,d products of photo-Fries rearrangement.
