17595-93-6Relevant articles and documents
Palladium-catalyzed decarbonylative suzuki-miyaura coupling of amides to achieve biaryls via C-N bond cleavage
Luo, Zhongfeng,Xiong, Li,Liu, Tingting,Zhang, Yuqi,Lu, Siqi,Chen, Yuwen,Guo, Weijie,Zhu, Yulin,Zeng, Zhuo
, p. 10559 - 10568 (2019/09/30)
The palladium-catalyzed decarbonylative Suzuki-Miyaura coupling of amides via selective amide C-N bond cleavage was reported, which afforded mild access to substitute biaryl products in the presence of low catalyst loading with NaHCO3 as the base in good yields within 4 h (29 examples).
First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases
Salah, Mohamed,Abdelsamie, Ahmed S.,Frotscher, Martin
supporting information, p. 4086 - 4092 (2017/05/19)
STS and 17β-HSD1 are attractive targets for the treatment of estrogen-dependent diseases like endometriosis and breast cancer. The simultaneous inhibition of both enzymes appears more promising than blockage of either protein alone. We describe a designed
Very efficient and broad-in-scope palladium-catalyzed Hiyama cross-coupling. the role of water and copper(I) salts
Traficante, Carla I.,Mata, Ernesto G.,Delpiccolo, Carina M. L.
, p. 26796 - 26800 (2015/03/30)
A very high-yielding Pd-catalyzed cross-coupling between aryl halides and aryl(trialkoxy)silanes is achieved in the presence of Cu(i) and a measured amount of water. This novel methodology is useful for the generation of a wide range of biaryls, particularly non-para substituted derivatives, which are usually less reported.
