176107-73-6Relevant articles and documents
Preparation and antirheumatic activity of optically active 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298)
Kameo, Kazuya,Takeshita, Kimiyo,Yasuda, Yoshiko,Matsumoto, Keita,Tomisawa, Kazuyuki
, p. 602 - 604 (1996)
2-Acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanonic acid (KE-298) is an antirheumatic agent. To elucidate the effects of optically active KE-298, we resolved the racemic acid and obtained the two optical isomers. ( + )-KE-298 was converted to the 4-bromo