176165-02-9

Basic information

• Product Name: (S)-1-(2-Methoxymethoxy-phenylamino)-butan-2-ol
• CAS NO: 176165-02-9
• Molecular Weight: 225.288
• Mol File: 176165-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(2-Methoxymethoxy-phenylamino)-butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(2-Methoxymethoxy-phenylamino)-butan-2-ol(176165-02-9)
• EPA Substance Registry System: (S)-1-(2-Methoxymethoxy-phenylamino)-butan-2-ol(176165-02-9)

Safety Data

• Hazardous Substances Data: 176165-02-9(Hazardous Substances Data)

Upstream product

• 30608-62-9 (S)-(-)-1,2-epoxybutane 
• 88733-56-6 2-methoxymethyloxy aniline 

Relevant articles and documents

Asymmetric cyclization of 3,4-dihydro-2-vinyl-2H-1,4-benzoxazine catalyzed by palladium-BHMP catalyst

The reaction of 1,4-diacetoxy-cis-2-butene 2a with 2-(benzylamino)phenol 3 in THF in the presence of Et3N and a catalytic amount of Pd(0)-BHMP-β-Ala 1c gave optically active 4-benzyl-2-vinylbenzoxazine of up to 56.2%ee. The reaction of (Z)-2-butene-1,4-diylbis(methylcarbonate) 2b instead of 2a with 2-(benzylamino)phenol 3, 4 was obtained with e.e up to 71.4%. We could improve the enantioselectivity of (R)-4 by introducing a carboxyl group at the terminal position of the pendant side chain on the bisphosphine ligand and by using a methyl carbonate ester 2b instead of diacetate 2a.