176236-88-7Relevant articles and documents
A general synthetic method for 2-substituted anthracenes
Dehaen, Wim,Corens, David,L'Abbe, Gerrit
, p. 201 - 203 (1996)
Anthracenes bearing a primary alkyl, ω-hydroxyalkyl, aryl or vinyl substituent at the 2-position are conveniently prepared by a copper-catalyzed Grignard reaction on 2,3-epoxy-1,2,3,4-tetrahydroanthracene, followed by dehydration - dehydrogenation of the resulting alcohols with tetrachloro-1,2-benzoquinone (o-chloranil).
Naphtho and benzo analogues of the κ opioid agonist trans-(±)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide
Freeman,Michalson,D'Andrea,Baczynskyj,VonVoigtlander,Lahti,Smith,Lawson,Scahill,Mizsak,Szmuszkovicz
, p. 1891 - 1896 (2007/10/02)
Further elaboration on the structure-activity relationships in our U-50,488 series has revealed that benzologation of this cyclohexane-1,2-diamine derivative provides compounds which either maintain the interaction with the κ receptor (e.g. compounds 3a a