176257-79-7

Basic information

• Product Name: (αS,2R)-methyl N-α-methylbenzyl-3-amino-2-methylpropanoate
• Synonyms: (αS,2R)-methyl N-α-methylbenzyl-3-amino-2-methylpropanoate
• CAS NO: 176257-79-7
• Molecular Weight: 221.299
• Mol File: 176257-79-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (αS,2R)-methyl N-α-methylbenzyl-3-amino-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (αS,2R)-methyl N-α-methylbenzyl-3-amino-2-methylpropanoate(176257-79-7)
• EPA Substance Registry System: (αS,2R)-methyl N-α-methylbenzyl-3-amino-2-methylpropanoate(176257-79-7)

Safety Data

• Hazardous Substances Data: 176257-79-7(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 80-62-6 methacrylic acid methyl ester 

Downstream Products

• 95350-09-7 (αS,3R)-1-α-methylbenzyl-3-methylazetidin-2-one 
• 64806-48-0 (αS,2R)-N-α-methylbenzyl-3-amino-2-methylpropionic acid 
• 182486-32-4 (R)-methyl 3-{[(tert-butoxy)carbonyl]amino}-2-methylpropionate 

Relevant articles and documents

Michael additions of amines to methyl acrylates promoted by microwave irradiation

A simple and efficient protocol has been developed for the Michael addition of amines to α,β-unsaturated esters under microwave irradiation. Under these conditions there was a significant decrease in the reaction time, increases in the yields and increased purity of the products.

3-Methylazetidin-2-one and its precursors: Optical resolution and absolute configurations

Enantiomers of 3-methylazetidin-2-one - (3R)-(+)- and (3S)-(-)-1 and 3-amino-2-methylpropionic acid - (2R)-(-)- and (2S)-(+)-2 were obtained from corresponding diastereomers of methyl (αS)-N-α-methylbenzyl-3-amino-2-methylpropionate 3A,B which had been separated by recrystallization of their salts 4A,B with p-toluenesulfonic acid. The absolute configurations of azetidinones (+)- and (-)-1 and their diastereomeric precursors, i.e. amino esters 3A,B, (αS)-N-α-methylbenzyl-3-amino-2-methylpropionic acids 5A,B, and (αS)-N-α-methylbenzyl-3-methylazetidin-2-ones 6A,B were established by conversion of (+)-1 to amino acid (2R)-(-)-2 and of amino acid (2S)-(+)-2 to (-)-1.