176375-44-3

Basic information

• Product Name: 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester
• Synonyms: 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester
• CAS NO: 176375-44-3
• Molecular Weight: 716.785
• Mol File: 176375-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester(176375-44-3)
• EPA Substance Registry System: 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester(176375-44-3)

Safety Data

• Hazardous Substances Data: 176375-44-3(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 176375-53-4 4-[4-(4-Hydroxy-butylcarbamoyloxymethyl)-2-methoxy-5-nitro-phenoxy]-butyric acid methyl ester 
• 176375-43-2 methyl 4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoate 
• 176375-42-1 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester 
• 176375-41-0 4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester 
• 121-33-5 vanillin 
• 3153-37-5 methyl 4-chlorobutyrate 

Downstream Products

• 176375-50-1 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid 

Relevant articles and documents

Novel solid phase synthesis supports for the preparation of oligonucleotides containing 3'-alkyl amines

The synthesis and application of photolabile supports for solid phase oligonucleotide synthesis that release oligonucleotides containing 3'-alkyl amines is described. The alkyl amine functionality can be revealed without removing any other protecting groups throughout the biopolymer. The solid phase synthesis supports do not contain a nucleoside, making it possible to use a single support for the synthesis of oligonucleotides independent of their sequence. Individual solid phase synthesis supports differ according to the length of the alkyl tether between the 4,4'-dimethoxytrityl group which serves as the initiation site for oligonucleotide synthesis and the latent alkyl amine. Eicosameric oligonucleotides are obtained in yields ranging from 70-98% under photolysis conditions that are known to produce less than 3% thymidine·thymidine photodimers. Longer oligonucleotides (30 and 40 nucleotides in length) are cleaved from these solid phase synthesis supports in lower yields.