17639-50-8

Basic information

• Product Name: 2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide
• Synonyms: 2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide;2-chloro-N-[2-(4-methoxyphenyl)ethyl]acetamide(SALTDATA: FREE)
• CAS NO: 17639-50-8
• Molecular Formula: C₁₁H₁₄ClNO₂
• Molecular Weight: 227.69
• Mol File: 17639-50-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 417.3°C at 760 mmHg
• Flash Point: 206.2°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 3.57E-07mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide(17639-50-8)
• EPA Substance Registry System: 2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide(17639-50-8)

Safety Data

• Hazardous Substances Data: 17639-50-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide is a chemical compound with the molecular formula C10H12ClNO2. It is a white crystalline solid that is commonly used as a building block in organic synthesis and pharmaceutical research. 2-Chloro-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide contains a chloro group, an acetamide group, and a methoxy-phenyl group, which makes it useful for the development of various pharmaceutical and agrochemical products. Its unique structure and properties make it a valuable tool for researchers and scientists in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C11H14ClNO2/c1-15-10-4-2-9(3-5-10)6-7-13-11(14)8-12/h2-5H,6-8H2,1H3,(H,13,14)

Upstream product

• 55-81-2 4-Methoxyphenethylamine 
• 79-04-9 chloroacetyl chloride 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1192358-65-8 2-azido-N-(4-methoxyphenethyl)acetamide 
• 305377-27-9 2-(1,3-Dioxoisoindolin-2-yl)-N-(4-methoxyphenethyl)acetamide 

Relevant articles and documents

Organocatalytic Cascade Reactions for the Diversification of Thiopyrano-Piperidone Fused Rings Utilizing Trienamine Activation

An aminocatalytic privileged diversity-oriented synthesis (ApDOS) strategy utilizing trienamine catalysis for the construction of diverse and complex thiopyrans-piperidone fused rings through a thia-Diels–Alder/nucleophilic ring-closing sequence by using dithioamides as activated heterodienophiles is reported. Following this strategy, a super cascade reaction to assemble nine fused rings can be achieved by employing a bis-dithioamide. Additionally, by linking an indole moiety on the dithioamide, a Pictet–Spengler type reaction can be promoted once the cascade sequence has been achieved, leading to more complex penta- hexa- and heptacyclic fused ring derivatives in a one-pot process. This investigation opens new perspectives for the synthesis of a new class of complex and diverse thiopyrans that contribute to populate new relevant regions in the chemical space.

Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof

The invention provides a novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and a preparation method and application thereof, and belongs to the field of chemical medicines. The derivative is a compound as shown in a formula I, or a salt thereof, or a stereoisomer thereof. The compound is low in toxicity or basically non-toxic to normal cells, has an obvious inhibition effect to tumor cell lines, particularly has good lipid toxicity selectivity to tumor cells such as liver cancer, lung cancer and the like in vivo, and has an obvious inhibition effect; meanwhile, the compound can effectively activate SREBP1 and PPAR gamma, inhibit lipid transport MTTP, cause lipid aggregation in tumor cells and cause lipid toxicity of the tumor cells. The compound can be used for treating liver cancer, lung cancer and the like in a molecular targeting manner, is low in toxicity or even non-toxic, and has a good application prospect.

Tetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Partial Agonists: Design, Synthesis, Structure-Activity Relationship, and Anticancer Activities

Tetrazanbigen (TNBG) is a novel sterol isoquinoline derivative with poor water solubility and moderate inhibitory effects on human cancer cell lines via lipoapoptosis induction. Herein, we developed a series of novel TNBG analogues with improved water sol