176439-43-3

Basic information

• Product Name: trans-N-benzoyl-4-mesyloxy-L-proline methyl ester
• Synonyms: trans-N-benzoyl-4-mesyloxy-L-proline methyl ester
• CAS NO: 176439-43-3
• Molecular Weight: 327.358
• Mol File: 176439-43-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-N-benzoyl-4-mesyloxy-L-proline methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: trans-N-benzoyl-4-mesyloxy-L-proline methyl ester(176439-43-3)
• EPA Substance Registry System: trans-N-benzoyl-4-mesyloxy-L-proline methyl ester(176439-43-3)

Safety Data

• Hazardous Substances Data: 176439-43-3(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 51-35-4 4R-4-hydroxyproline 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 31560-20-0 (2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 176439-46-6 (S)-2-[((2S,4S)-1-Benzoyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid ethyl ester 
• 176439-45-5 (2S,4S)-1-Benzoyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carboxylic acid 
• 176439-44-4 N-α-benzoyl-cis-4-amino-L-proline 
• 129155-63-1 N-benzoyl-4-trans-(methanesulfonyloxy)-L-proline 
• 84520-72-9 (4S)-1-benzoyl-1-azido-L-proline methyl ester 

Relevant articles and documents

Cyclopropenone catalyzed substitution of alcohols with mesylate ion

The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.