176486-05-8

Basic information

• Product Name: (S)-N-Ethyl-N-heptyl-4-hydroxy-4-(4-methanesulfonylamino-phenyl)-butyramide
• Synonyms: (S)-N-Ethyl-N-heptyl-4-hydroxy-4-(4-methanesulfonylamino-phenyl)-butyramide
• CAS NO: 176486-05-8
• Molecular Weight: 398.567
• Mol File: 176486-05-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-Ethyl-N-heptyl-4-hydroxy-4-(4-methanesulfonylamino-phenyl)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Ethyl-N-heptyl-4-hydroxy-4-(4-methanesulfonylamino-phenyl)-butyramide(176486-05-8)
• EPA Substance Registry System: (S)-N-Ethyl-N-heptyl-4-hydroxy-4-(4-methanesulfonylamino-phenyl)-butyramide(176486-05-8)

Safety Data

• Hazardous Substances Data: 176486-05-8(Hazardous Substances Data)

Upstream product

• 100632-58-4 N-<4-<4-(ethyl-n-heptylamino)-1,4-dioxo-butyl>phenyl>methanesulfonamide 

Relevant articles and documents

Synthesis of (R)-N-[4-[4-(dibutylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (artilide fumarate) and the enantiomers of N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate)

Syntheses of artilide fumarate, its (S) enantiomer and the (R) and (S) enantiomers of ibutilide fumarate were achieved by reduction of the prochiral ketones with (+) and (-)-B-chlorodiisopinocampheylborane. Several methods for analyzing the optical purity of these compounds are presented. The absolute configurations were established by a single crystal X-ray crystallographic analysis of (S)-N-[4-[4-(dibutylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide. Copyright