176526-00-4

Basic information

• Product Name: 2-(4-Pyridyl)benzaldehyde
• Synonyms: 2-(4-PYRIDINYL)BENZALDEHYDE;2-(4-PYRIDYL)BENZALDEHYDE;2-PYRIDIN-4-YL-BENZALDEHYDE;AKOS BAR-1759;2-Pyridin-4-yl-benzaldehyd;2-PYRIDIN-4-YL-BENZALDEHYDE, 95+%
• CAS NO: 176526-00-4
• Molecular Formula: C₁₂H₉NO
• Molecular Weight: 183.21
• Product Categories: Heterocycles;Heterocyclic Compound;Benzaldehyde
• Mol File: 176526-00-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 342.797 °C at 760 mmHg
• Flash Point: 169.065 °C
• Appearance: /
• Density: 1.148 g/cm³
• Vapor Pressure: 7.35E-05mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Pyridyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Pyridyl)benzaldehyde(176526-00-4)
• EPA Substance Registry System: 2-(4-Pyridyl)benzaldehyde(176526-00-4)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 176526-00-4(Hazardous Substances Data)

Usage

General Description

2-(4-Pyridyl)benzaldehyde is a chemical compound with the molecular formula C12H9NO. It is a yellow to brown crystalline solid that is commonly used as a chemical intermediate and building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. 2-(4-Pyridyl)benzaldehyde possesses an aromatic benzene ring and a pyridine ring, and it is commonly used as a reagent in chemical reactions due to its ability to form complex organic molecules. It is also known for its characteristic odor and is commonly used in the fragrance industry. Additionally, it finds applications in the synthesis of chiral ligands and as a fluorescent probe for cellular imaging.

InChI:InChI=1/C12H9NO/c14-9-11-3-1-2-4-12(11)10-5-7-13-8-6-10/h1-9H

Upstream product

• 1120-87-2 4-bromopyridin 
• 40138-16-7 2-formylbenzene boronic acid 
• 1692-15-5 4-pyridylboronic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 19524-06-2 4-bromopyridine hydrochloride 

Downstream Products

• 216443-81-1 4-[2-((E)-2-iodovinyl)phenyl]pyridine 
• 1022134-79-7 methyl 2-[1-hydroxy-1-{2-(pyridin-4-yl)phenyl}methyl]propenoate 
• 1033804-66-8 2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)ethanol 
• 1332500-54-5 4-methyl-N'-(2-(pyridin-4-yl)benzylidene)benzenesulfonohydrazide 
• 1375801-19-6 4-[2-(2-iodovinyl)phenyl]pyridine 
• 870063-38-0 4-(2-(azidomethyl)phenyl)pyridine 
• 83420-56-8 4-(2-ethynylphenyl)pyridine 
• 1033804-65-7 (S)-2-amino-3-(4-{6-[2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)-ethoxy]-pyrimidin-4-yl}-phenyl)-propionic acid 
• 1033804-67-9 4-chloro-6-[2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)ethoxy]pyrimidine 

Relevant articles and documents

A route to dihydro[2]benzooxepino[4,5-c]pyridines and dihydrothieno[d][2]benzooxepines via the 1.7-electrocyclisation of carbonyl ylides

The cyclisation of diene-conjugated carbonyl ylides of the general type 2, in which the α,β; γ,δ diene function is formed by a benzene ring and either a thiophene or pyridine ring provides a new route to some hetero-fused dihydrobenzooxepines. The oxirane

Silver-Catalyzed Tandem C=C Bond Hydroazidation/Radical Addition/Cyclization of Biphenyl Acetylene: One-Pot Synthesis of 6-Methyl Sulfonylated Phenanthridines

A silver-catalyzed tandem carbon-carbon triple bond hydroazidation, radical addition, and cyclization of biphenyl acetylene is described under mild conditions, leading to the formation of 6-methyl sulfonylated phenanthridines in good yields. In this novel cascade reaction, most of the atoms are incorporated into the product without cleavage of the C=C bond. Mechanistic studies suggest the reaction should proceed through an iminyl radical reactive intermediate.

Phosphine-Free Suzuki Cross-Coupling Reaction Using an Efficient and Reusable Pd Catalyst in an Aqueous Medium under Microwave Irradiation

We report here an improved, highly efficient, and general method for the ligand-free Suzuki cross-coupling reaction to the synthesis of biaryls, bipyridyls, thienylpyridine, and allylphenols. Microwave irradiation of (het)aryl halides and (hetaryl, allyl)arylboronic acid N-methyl-iminodiacetic acid (MIDA) ester, using polyurea microencapsulated palladium catalyst (Pd EnCat 30), gave the coupling adducts 1a-x in excellent yields in just 10-18 min.