176714-22-0

Basic information

• Product Name: (S)-3-{(2S,4R)-2-[(2S,3aS,6aS)-2-(Benzyl-methyl-carbamoyl)-hexahydro-cyclopenta[b]pyrrole-1-carbonyl]-4-hydroxy-pyrrolidine-1-carbonyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• CAS NO: 176714-22-0
• Molecular Weight: 630.784
• Mol File: 176714-22-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-{(2S,4R)-2-[(2S,3aS,6aS)-2-(Benzyl-methyl-carbamoyl)-hexahydro-cyclopenta[b]pyrrole-1-carbonyl]-4-hydroxy-pyrrolidine-1-carbonyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-{(2S,4R)-2-[(2S,3aS,6aS)-2-(Benzyl-methyl-carbamoyl)-hexahydro-cyclopenta[b]pyrrole-1-carbonyl]-4-hydroxy-pyrrolidine-1-carbonyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(176714-22-0)
• EPA Substance Registry System: (S)-3-{(2S,4R)-2-[(2S,3aS,6aS)-2-(Benzyl-methyl-carbamoyl)-hexahydro-cyclopenta[b]pyrrole-1-carbonyl]-4-hydroxy-pyrrolidine-1-carbonyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(176714-22-0)

Safety Data

• Hazardous Substances Data: 176714-22-0(Hazardous Substances Data)

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 171856-33-0 (2S,3aS,6aS)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl-methyl-amide 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 124002-32-0 (2S,3aS,6aS)-1-[(tert-butoxy)carbonyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 

Relevant articles and documents

Modification of the potent peptide FK888 with unusual aminoacids: Effects on activity on neurokinin receptors

We report on the synthesis and the pharmacological properties of a new series of tachykinin antagonists based on the peptide N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N-m ethyl-N-(phe-nylmethyl)-3-(2-naphthyl)-L-alaninamide (FK888) modified on the (2-naphthyl)-L-alanine and the [(1-methyl-1H-indol-3-yl)carbonyl] moieties. The compounds were tested on guinea pig ileum for NK-1, rat colon for NK-2 and rat portal vein for NK-3 receptors. The two most potent peptides of this series, 1b and 2d, were selective for the NK-2 receptor (pA2 = 7.5 and 7.3, respectively).