1769-85-3

Basic information

• Product Name: (±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid
• Synonyms: (±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid
• CAS NO: 1769-85-3
• Molecular Weight: 256.301
• Mol File: 1769-85-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid(1769-85-3)
• EPA Substance Registry System: (±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid(1769-85-3)

Safety Data

• Hazardous Substances Data: 1769-85-3(Hazardous Substances Data)

Upstream product

• 30292-50-3 (E)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid 
• 100-52-7 benzaldehyde 
• 104-47-2 p-methoxybenzylnitrile 
• 5840-59-5 3-phenyl-2-(4-methoxyphenyl)acrylonitrile 
• 5840-58-4 2-(4-methoxyphenyl)-3-phenylpropanenitrile 
• 104-01-8 4-Methoxyphenylacetic acid 
• 100-44-7 benzyl chloride 
• 1694-22-0 (E)-2-(4-methoxyphenyl)-3-phenylacrylic acid 

Downstream Products

• 145962-41-0 2-(4-methoxyphenyl)indanamine 
• 145962-42-1 2-(4-methoxyphenyl)-1-indanone oxime methyl ether 
• 102345-54-0 2-<4-Methoxy-phenyl>-3-<4-(2-diaethylamino-aethoxy)-phenyl>-inden 
• 39104-22-8 3-Phenyl-2-<4-methoxy-phenyl>-propionsaeure-chlorid 
• 1086-43-7 2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

Inhibitors of acyl CoA:cholesterol acyltransferase

Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4- Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 μM in an in vitro rat hepatic microsomal ACAT assay, ED50 = 0.72 mg/kg/day in cholesterol-fed hamsters).