17708-87-1 Usage
Description
(R,S)-NORCOTININE, also known as a metabolite of (+/-)-Cotinine, is a chemical compound derived from the metabolism of Cotinine. It is characterized by its colorless crystalline structure. (R,S)-NORCOTININE is a promising compound with potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
(R,S)-NORCOTININE is used as an intermediate compound for the synthesis of various pharmaceutical products. Its role in the metabolism of Cotinine makes it a valuable component in the development of drugs targeting nicotine addiction and related health issues.
Used in Chemical Research:
As a metabolite of Cotinine, (R,S)-NORCOTININE is used as a research tool in the field of chemical research. It aids in understanding the metabolic pathways of nicotine and its derivatives, which can contribute to the development of new treatments for nicotine dependence and other related conditions.
Used in Analytical Chemistry:
(R,S)-NORCOTININE's colorless crystalline structure makes it a useful reference material in analytical chemistry. It can be employed as a standard for the calibration of instruments and the development of new analytical methods for the detection and quantification of Cotinine and its metabolites in various samples, such as biological fluids and environmental matrices.
Check Digit Verification of cas no
The CAS Registry Mumber 17708-87-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,0 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17708-87:
(7*1)+(6*7)+(5*7)+(4*0)+(3*8)+(2*8)+(1*7)=131
131 % 10 = 1
So 17708-87-1 is a valid CAS Registry Number.
17708-87-1Relevant articles and documents
Electroreductive coupling of aromatic ketones, aldehydes, and aldimines with α,β-unsaturated esters: Synthesis of 5-aryl substituted γ-butyrolactones and lactams
Kise, Naoki,Hamada, Yusuke,Sakurai, Toshihiko
, p. 1143 - 1156 (2017/02/18)
The electroreductive intermolecular coupling of aromatic ketones and aldehydes with α,β-unsaturated esters in the presence of TMSCl gave the adducts as γ-trimethylsiloxy esters. The detrimethylsilylation of the adducts with TBAF afforded 5-aryl substituted γ-butyrolactones. The electroreductive coupling of N-(4-methoxyphenyl)-1-arylmethaneimines with methyl acrylate in the presence of TMSCl gave the adducts as methyl 4-aryl-4-((4-methoxyphenyl)amino)butanoates. The adducts were transformed to 5-aryl-γ-butyrolactams by cyclization with NaH and subsequent oxidation with CAN. (±)-Norcotinine was prepared from nicotinaldehyde by this method. The electroreductive coupling of aromatic ketones and aldimines with acrylonitrile in the presence of TMSCl gave 4-aryl-4-(trimethylsiloxy)butanenitriles and 4-aryl-4-((4-methoxyphenyl)amino)butanenitriles, respectively.
