177080-77-2 Usage
Description
(3beta,5alpha)-3-hydroxy-3-(trifluoromethyl)pregnan-20-one, also known as trilostane, is a synthetic steroid with a molecular formula of C21H29F3O2. It belongs to the pregnane class of steroids and is characterized by the presence of a trifluoromethyl group. Trilostane exhibits unique properties due to its chemical structure, making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Trilostane is used as a medication for the treatment of Cushing's syndrome, a hormonal disorder characterized by an excess of cortisol in the body. It functions by inhibiting the enzyme 3-beta-hydroxysteroid dehydrogenase, which is crucial in the biosynthesis of cortisol. By doing so, trilostane helps to reduce the production of cortisol in the adrenal glands, effectively managing the symptoms of Cushing's syndrome such as weight gain, high blood pressure, and diabetes. This makes trilostane an important therapeutic agent in the management of this condition.
Check Digit Verification of cas no
The CAS Registry Mumber 177080-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,0,8 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 177080-77:
(8*1)+(7*7)+(6*7)+(5*0)+(4*8)+(3*0)+(2*7)+(1*7)=152
152 % 10 = 2
So 177080-77-2 is a valid CAS Registry Number.
177080-77-2Relevant articles and documents
C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
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, (2018/03/25)
Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.
Synthesis and in vitro activity of 3β-substituted-3α-hydroxypregnan- 20-ones: Allosteric modulators of the GABA(A) receptor
Hogenkamp, Derk J.,Tahir, S. Hasan,Hawkinson, Jon E.,Upasani, Ravi B.,Alauddin, Mian,Kimbrough, Catherine L.,Acosta-Burruel, Manuel,Whittemore,Woodward,Lan, Nancy C.,Gee, Kelvin W.,Bolger, Michael B.
, p. 61 - 72 (2007/10/03)
Two naturally occurring metabolites of progesterone, 3α-hydroxy-5α- and 5β-pregnan-20-one (1 and 2), are potent allosteric modulators of the GABA(A) receptor. Their therapeutic potential as anxiolytics, anticonvulsants, and sedative/hypnotics is limited b
