17720-18-2 Usage
Description
Nicotinic acid ribonucleoside (NR) is a naturally occurring compound and a precursor to nicotinamide adenine dinucleotide (NAD+), which plays a crucial role in cellular metabolism and energy production. It is a white solid and is found in various foods, including meats and certain vegetables.
Uses
Used in Pharmaceutical Industry:
Nicotinic acid ribonucleoside is used as a supplement for enhancing cellular NAD+ levels, which is essential for maintaining cellular health and energy metabolism. The increased NAD+ concentrations can have various beneficial effects on the body, such as improving mitochondrial function, supporting DNA repair, and promoting overall cellular health.
Used in Anti-Aging Applications:
In the field of anti-aging, nicotinic acid ribonucleoside is used as a rejuvenating agent to boost NAD+ levels, which decline with age. By replenishing NAD+, it may help to slow down the aging process and improve the overall health and vitality of cells.
Used in Neuroprotection:
Nicotinic acid ribonucleoside is also used as a neuroprotective agent due to its role in maintaining healthy NAD+ levels in the brain. Adequate NAD+ levels are important for supporting brain function and may help protect against neurodegenerative diseases.
Used in Sports Nutrition:
In the sports nutrition industry, NR is used as a performance enhancer to improve energy levels and support muscle recovery. The increased NAD+ levels can help to optimize cellular energy production, which may lead to better athletic performance and faster recovery times.
Used in Cosmetics:
In the cosmetics industry, nicotinic acid ribonucleoside is used as an ingredient in anti-aging skincare products. The compound's ability to boost NAD+ levels can help to improve skin health, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion.
Overall, nicotinic acid ribonucleoside is a versatile compound with a wide range of applications in various industries, primarily due to its role in supporting cellular health and energy metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 17720-18-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,2 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17720-18:
(7*1)+(6*7)+(5*7)+(4*2)+(3*0)+(2*1)+(1*8)=102
102 % 10 = 2
So 17720-18-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO6/c13-5-7-8(14)9(15)10(18-7)12-3-1-2-6(4-12)11(16)17/h1-4,7-10,13-15H,5H2/t7-,8-,9-,10-/m1/s1
17720-18-2Relevant articles and documents
Scalable syntheses of traceable ribosylated NAD+ precursors
Makarov,Harris,Rodrigues,Migaud
supporting information, p. 8716 - 8720 (2019/10/16)
Nicotinamide adenine dinucleotide, NAD+, is an essential cofactor and substrate for many cellular enzymes. Its sustained intracellular levels have been linked to improved physiological end points in a range of metabolic diseases. Biosynthetic precursors to NAD+ include nicotinic acid, nicotinamide, the ribosylated parents and the phosphorylated form of the ribosylated parents. By combining solvent-assisted mechanochemistry and sealed reaction conditions, access to the ribosylated NAD+ precursors and to the isotopologues of NAD+ precursors was achieved in high yields and levels of purity. The latter is critical as it offers means to better trace biosynthetic pathways to NAD+, investigate the multifaceted roles of the intracellular NAD+ pools, and better exploit NAD+ biology.
Syntheses of nicotinamide riboside and derivatives: Effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells
Yang, Tianle,Chan, Noel Yan-Ki,Sauve, Anthony A.
, p. 6458 - 6461 (2008/03/27)
A new two-step methodology achieves stereoselective synthesis of β-nicotinamide riboside and a series of related amide, ester, and acid nucleosides. Compounds were prepared through a triacetylatednicotinate ester nucleoside, via coupling of either ethylnicotinate or phenylnicotinate with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose. Nicotinamide riboside, nicotinic acid riboside, O-ethylnicotinate riboside, O-methylnicotinate riboside, and several N-alkyl derivatives increased NAD+ concentrations from 1.2-2.7-fold in several mammalian cell lines. These findings establish bioavailability and potent effects of these nucleosides in stimulating the increase of NAD+ concentrations in mammalian cells.
