177211-26-6

Basic information

• Product Name: 4'-CHLORO-2'-FLUORO-5'-METHYLACETOPHENONE
• Synonyms: 1-(4-Chloro-2-fluoro-5-methylphenyl)ethan-1-one, 5-Acetyl-2-chloro-4-fluorotoluene;1-(4-Chloro-2-fluoro-5-Methylphenyl)ethanone;5'-chloro-2'-fluoro-4'-Methylacetophenone;4'-Chloro-2'-fluoro-5'-Methylacetophenone (>90%);1-(4-Chloro-2-fluoro-5-methylphenyl)
• CAS NO: 177211-26-6
• Molecular Formula: C₉H₈ClFO
• Molecular Weight: 186.61
• Mol File: 177211-26-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 258.4°C at 760 mmHg
• Flash Point: 110.1°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4'-CHLORO-2'-FLUORO-5'-METHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLORO-2'-FLUORO-5'-METHYLACETOPHENONE(177211-26-6)
• EPA Substance Registry System: 4'-CHLORO-2'-FLUORO-5'-METHYLACETOPHENONE(177211-26-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 177211-26-6(Hazardous Substances Data)

Usage

Description

4'-Chloro-2'-fluoro-5'-methylacetophenone is an organic compound characterized by its unique molecular structure, which features a chlorine atom at the 4' position, a fluorine atom at the 2' position, and a methyl group at the 5' position. 4'-CHLORO-2'-FLUORO-5'-METHYLACETOPHENONE is known for its potential applications in various chemical and pharmaceutical processes due to its distinct properties.

Uses

Used in Chemical Synthesis:
4'-Chloro-2'-fluoro-5'-methylacetophenone is used as a reagent in the synthesis of 3-Aryl-5-hydroxyl-5-trifluoromethylisoxazolines. These compounds are important intermediates in the production of protox-inhibiting herbicides, which are widely used in agriculture to control the growth of unwanted plants and weeds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4'-chloro-2'-fluoro-5'-methylacetophenone may be utilized as a key intermediate in the development of new drugs or drug candidates. Its unique molecular structure can be exploited to create novel compounds with potential therapeutic applications, such as in the treatment of various diseases or conditions.
Used in Research and Development:
4'-Chloro-2'-fluoro-5'-methylacetophenone can also be employed in research and development settings, where it may be used to study the effects of different functional groups on the properties and reactivity of organic compounds. This can lead to a better understanding of the underlying chemical principles and contribute to the discovery of new synthetic routes and methodologies.

InChI:InChI=1/C9H8ClFO/c1-5-3-7(6(2)12)9(11)4-8(5)10/h3-4H,1-2H3

Upstream product

• 452-73-3 2-chloro-4-fluorotoluene 
• 75-36-5 acetyl chloride 

Downstream Products

• 177211-21-1 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-4,4,4-trifluoro-1,3-butanedione 
• 142623-48-1 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole 
• 142623-96-9 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-5-(trifluoromethyl)-1H-pyrazole 
• 177489-17-7 2-chloro-4-fluoro-5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-benzoic acid 
• 200624-30-2 5-(4-bromo-1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-2-chloro-4-fluoro-benzoyl chloride 
• 174514-08-0 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid 
• 757245-87-7 tert-butyl 4-(2-acetyl-5-chloro-4-methylphenyl)piperazine-1-carboxylate 
• 177211-31-3 4-chloro-2-fluoro-5-methylbenzoic acid 

Relevant articles and documents

ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention

Substituted 3-phenylisoxazolines

PCT No. PCT/EP98/04489 Sec. 371 Date Jan. 21, 2000 Sec. 102(e) Date Jan. 21, 2000 PCT Filed Jul. 20, 1998 PCT Pub. No. WO99/05130 PCT Pub. Date Feb. 4, 1999Substituted 3-phenylisoxazolines I, and their salts and enol ethers, are described as herbicides where X=-O-, -S-, -N(R9)-; R1=CN, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-alkylsulfonyl; R2=H or unsubstituted or substituted C1-C6-alkyl, (C1-C6-alkyl)carbonyl, C1-C6-alkylsulfonyl, C2-C6-alkenyl, (C2-C6-alkenyl)carbonyl, C2-C6-alkynyl, (C2-C6-alkynyl)carbonyl; R3=H, halogen; R4=CN, halogen, C1-C3-haloalkyl; R5=H, CN, halogen, C1-C3-haloalkyl; R6=H, CN, halogen, C1-C3-haloalkyl or unsubstituted or substituted C1-C6-alkoxy; R7=CN, halogen; R8 in position alpha , R7 in this case being in position beta , or in position beta , R7 in this case being in position alpha , is 1) H, OH, SH, CN, NO2, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-haloalkylthio, C1-C6-alkylthio-(C1-C6-alkyl)carbonyl, (C1-C6-alkyl)iminooxycarbonyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxyamino-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkylamino-C1-C6-alkyl, 2) unsubstituted or substituted C1-C6-alkoxy, C1-C6-alkylthio, C3-C6-cycloalkoxy, C3-C6-cycloalkylthio, C2-C6-alkenyloxy, C2-C6-alkenylthio, C2-C6-alkynyloxy, C2-C6-alkynylthio, (C1-C6-alkyl)carbonyloxy, (C1-C6-alkyl)carbonylthio, (C1-C6-alkoxy)carboxyloxy, (C2-C6-alkenyl)carbonyloxy, (C2-C6-alkenyl)carbonylthio, (C2-C6-alkynyl)carbonyloxy, (C2-C6-alkynyl)carbonylthio, C1-C6-alkylsulfonyloxy or C1-C6-alkylsulfonyl, 3) 29 further radicals; R9=H, C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-alkenyl, C3-C6-alkynyl, C1-C6-alkoxy-C1-C6-alkyl, (C1-C6-alkoxy)carbonyl-C1-C6-alkyl, (C3-C6-alkenyloxy)carbonyl-C1-C6-alkyl, unsubstituted or substituted phenyl or phenyl-C1-C6-alkyl.