17722-71-3 Usage
Description
N-(3,4-DICHLORO-PHENYL)-SUCCINAMIC ACID, a white crystalline solid with the molecular formula C10H9Cl2NO3, is a chemical compound belonging to the succinamic acid family. It is commonly utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, showcasing potential applications in both industries due to its unique structure and properties.
Uses
Used in Pharmaceutical Industry:
N-(3,4-DICHLORO-PHENYL)-SUCCINAMIC ACID is used as a building block for the synthesis of various drugs, contributing to the development of new compounds with therapeutic value.
Used in Agrochemical Industry:
N-(3,4-DICHLORO-PHENYL)-SUCCINAMIC ACID is used as a component in the creation of herbicides and pesticides, enhancing the effectiveness of these products in agricultural applications.
Additionally, due to its potential biological activity, N-(3,4-DICHLORO-PHENYL)-SUCCINAMIC ACID serves as a valuable tool for researchers and chemists in exploring and developing new compounds with either medicinal or agricultural significance.
Check Digit Verification of cas no
The CAS Registry Mumber 17722-71-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,2 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 17722-71:
(7*1)+(6*7)+(5*7)+(4*2)+(3*2)+(2*7)+(1*1)=113
113 % 10 = 3
So 17722-71-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H10Cl2N2O2/c11-7-2-1-6(5-8(7)12)14-10(16)4-3-9(13)15/h1-2,5H,3-4H2,(H2,13,15)(H,14,16)
17722-71-3Relevant articles and documents
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor
Kany, Andreas M.,Sikandar, Asfandyar,Yahiaoui, Samir,Haupenthal, J?rg,Walter, Isabell,Empting, Martin,K?hnke, Jesko,Hartmann, Rolf W.
, p. 2449 - 2455 (2018/09/06)
In search of novel antibiotics to combat the challenging spread of resistant pathogens, bacterial proteases represent promising targets for pathoblocker development. A common motif for protease inhibitors is the hydroxamic acid function, yet this group has often been related to unspecific inhibition of various metalloproteases. In this work, the inhibition of LasB, a harmful zinc metalloprotease secreted by Pseudomonas aeruginosa, through a hydroxamate derivative is described. The present inhibitor was developed based on a recently reported, highly selective thiol scaffold. Using X-ray crystallography, the lack of inhibition of a range of human matrix metalloproteases could be attributed to a distinct binding mode sparing the S1′ pocket. The inhibitor was shown to restore the effect of the antimicrobial peptide LL-37, decrease the formation of P. aeruginosa biofilm and, for the first time for a LasB inhibitor, reduce the release of extracellular DNA. Hence, it is capable of disrupting several important bacterial resistance mechanisms. These results highlight the potential of protease inhibitors to fight bacterial infections and point out the possibility to achieve selective inhibition even with a strong zinc anchor.