17734-41-7

Basic information

• Product Name: 7-CHLORO-1-OXO-1-PHENYLHEPTANE
• Synonyms: 7-CHLORO-1-OXO-1-PHENYLHEPTANE;LABOTEST-BB LT00248642
• CAS NO: 17734-41-7
• Molecular Formula: C₁₃H₁₇ClO
• Molecular Weight: 224.73
• Mol File: 17734-41-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 334.8°C at 760 mmHg
• Flash Point: 193.1°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 0.000125mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 7-CHLORO-1-OXO-1-PHENYLHEPTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-1-OXO-1-PHENYLHEPTANE(17734-41-7)
• EPA Substance Registry System: 7-CHLORO-1-OXO-1-PHENYLHEPTANE(17734-41-7)

Safety Data

• Hazardous Substances Data: 17734-41-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 4513, 1988 DOI: 10.1016/S0040-4039(00)80534-1

InChI:InChI=1/C13H17ClO/c14-11-7-2-1-6-10-13(15)12-8-4-3-5-9-12/h3-5,8-9H,1-2,6-7,10-11H2

Upstream product

• 54771-63-0 7-chloroheptanoic acid chloride 
• 71-43-2 benzene 
• 2082-21-5 1-phenylcycloheptanol 
• 6294-17-3 1-bromo-6-chlorohexane 
• 98-88-4 benzoyl chloride 
• 54512-75-3 1-bromo-5-chloropentane 
• 13466-32-5 acetophenone dimethylhydrazone 
• 34683-73-3 1-chloro-6-iodohexane 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 936-59-4 3-chloropropiophenone 
• 37908-41-1 1-hydroperoxy-1-phenylcycloheptane 

Downstream Products

• 17734-24-6 Essigsaeure-ζ-benzoyl-hexylester 
• 36741-70-5 7-chloro-1-phenylheptan-1-ol 
• 38235-31-3 1-Benzamido-7-diethylamino-1-phenylheptan 
• 1218989-36-6 (S,E)-N-(7-chloro-1-phenylhexylidene)-2-methylpropane-2-sulfinamide 
• 1246767-95-2 9-(7-oxo-7-phenylheptyl)guanine 
• 1246767-96-3 7-(7-oxo-7-phenylheptyl)guanine 
• 1246768-12-6 1-(7-hydroxy-7-phenylheptyl)uracil 
• 1246768-15-9 1-(7-hydroxy-7-phenylheptyl)thymine 
• 1246768-19-3 1-(7-hydroxy-7-phenylheptyl)cytosine 
• 1246768-22-8 9-(7-hydroxy-7-phenylheptyl)hypoxantine 
• 1246768-24-0 9-(7-hydroxy-7-phenylheptyl)adenine 
• 1246767-89-4 1-(7-oxo-7-phenylheptyl)cytosine 
• 1246767-93-0 N²-(2-methylpropionyl)-9-(7-oxo-7-phenylheptyl)guanine 
• 1246767-94-1 N²-(2-methylpropionyl)-7-(7-oxo-7-phenylheptyl)guanine 

Relevant articles and documents

Copper-catalyzed radical ring-opening halogenation with HX

An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields. This journal is

Far-end halogenated alkyl ketone taking HX as halogen source and synthesis method of far-end halogenated alkyl ketone

The invention relates to a far-end halogenated alkyl ketone taking HX as a halogen source and a synthesis method of the far-end halogenated alkyl ketone. The method comprises the following steps that: cycloalkyl peroxy alcohol and a copper acetate catalyst are added in a nitrogen atmosphere, then HCl, HBr and an HI solution are added as halogens, and stirring is carried out at normal temperature; after a reaction is finished, sufficient water is added to extract a reaction solvent N-methyl pyrrolidone, performing washing with saturated saline solution, an organic phase is dried with anhydrous sodium sulfate, the organic phase is concentrated under reduced pressure, so that the solvent can be removed; and column chromatography is performed on the organic phase to obtain a target product. According to the far-end halogenated alkyl ketone taking the HX as the halogen source and the synthesis method of the far-end halogenated alkyl ketoneinvention, industrial bulk raw materials HCl, HBr and an HI solution are used as the halogen source, free radical halogenation of C-C bond cracking is realized, and the far-end halogenated alkyl alkyl ketone compound is obtained with high yield; the byproduct of the reaction is water, so that the environmental pollution is reduced, and the industrial production benefit is greatly improved.

Regioselective Synthesis of Carbonyl-Containing Alkyl Chlorides via Silver-Catalyzed Ring-Opening Chlorination of Cycloalkanols

A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp3)-C(sp3) bond cleavage and C(sp3)-Cl bond formation efficiently occur with good yields under mild conditions, and the chlorinated products are readily transformed into other useful synthetic intermediates and drugs. The reaction features complete regioselectivity, high efficiency, and excellent practicality. (Chemical Equation Presented).