177533-37-8

Basic information

• Product Name: 2-amino-6-O-(p-toluenesulfonyl)-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine
• Synonyms: 2-amino-6-O-(p-toluenesulfonyl)-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine
• CAS NO: 177533-37-8
• Molecular Weight: 649.959
• Mol File: 177533-37-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-6-O-(p-toluenesulfonyl)-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-O-(p-toluenesulfonyl)-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine(177533-37-8)
• EPA Substance Registry System: 2-amino-6-O-(p-toluenesulfonyl)-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine(177533-37-8)

Safety Data

• Hazardous Substances Data: 177533-37-8(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 961-07-9 2'-Deoxyguanosine 
• 51549-35-0 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1007318-18-4 C₅₀H₈₄N₁₀O₆Si₄ 
• 1287240-37-2 2-phenoxyacetylamino-6-(2,2'-bithien-5-yl)-9-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)purine 2-cyanoethyl-N,N-diisopropylaminophosphoramidite 
• 1287240-36-1 2-phenoxyacetylamino-6-(2,2'-bithien-5-yl)-9-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)purine 
• 1287240-35-0 2-phenoxyacetylamino-6-(2,2'-bithien-5-yl)-9-(2-deoxy-β-D-ribofuranosyl)purine 
• 1253890-40-2 2-amino-6-[4-(methyl)phenylethynyl]-9-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentafuranosyl]purine 
• 1253890-41-3 2-amino-6-[4-(methoxy)phenylethynyl]-9-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentafuranosyl]purine 
• 1253890-37-7 2-amino-6-[phenylethynyl]-9-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentafuranosyl]purine 
• 1253890-42-4 2-amino-6-[4-(formyl)phenylethynyl]-9-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentafuranosyl]purine 
• 1253890-39-9 2-amino-6-[2-(methoxy)phenylethynyl]-9-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentafuranosyl]purine 
• 1253890-38-8 2-amino-6-[2-(methyl)phenylethynyl]-9-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentafuranosyl]purine 
• 848613-84-3 2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-[2-deoxy-5-O-(4,4'-dimethoxytrityk)-β-D-ribofuranosyl]purine 
• 848613-83-2 2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine 

Relevant articles and documents

Facile Cu-free Sonogashira cross-coupling of nucleoside C-6 arylsulfonates with terminal alkynes

The combination of PdCl2[CH3CN]2 with XPhos is an efficient catalytic system for the Sonogashira-type cross-coupling of 2′-deoxyguanosine O6-arylsulfonates with terminal alkynes. The reactions generally proceed under mild conditions requiring no Cu co-catalyst to give the corresponding C-6-alkynylated deoxynucleosides in moderate to good yields.

Mild and room temperature C-C bond forming reactions of nucleoside C-6 arylsulfonates

Palladium catalyzed cross coupling of nucleoside arylsulfonates and arylboronic acids has been accomplished under mild conditions and at room temperature. Among three structurally similar ligands that differ in their steric and electronic properties, one