17758-13-3

Basic information

• Product Name: 1-Phenylpyrimidin-2(1H)-one
• Synonyms: 1-Phenylpyrimidin-2(1H)-one
• CAS NO: 17758-13-3
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18332
• Mol File: 17758-13-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Phenylpyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenylpyrimidin-2(1H)-one(17758-13-3)
• EPA Substance Registry System: 1-Phenylpyrimidin-2(1H)-one(17758-13-3)

Safety Data

• Hazardous Substances Data: 17758-13-3(Hazardous Substances Data)

Usage

Heterocyclic compound

pyrimidine ring with a phenyl group and a ketone group
1-Phenylpyrimidin-2(1H)-one is a heterocyclic compound, meaning it contains a ring structure with more than one type of atom. In this case, it has a pyrimidine ring with a phenyl group attached at the 1-position and a ketone group at the 2-position.

Potential applications

medicinal and pharmaceutical chemistry
This compound has potential applications in the field of medicinal and pharmaceutical chemistry, as it can serve as a scaffold for the development of new drugs.

Biological activity

potential therapeutic effects
1-Phenylpyrimidin-2(1H)-one may exhibit biological activity, which means it could have potential therapeutic effects and be studied for its possible uses in treating various conditions.

Building block in organic synthesis

preparation of various chemical compounds
The compound may also be used as a building block in organic synthesis, allowing for the preparation of various other chemical compounds.

Further research and testing needed

properties and potential uses
Despite its potential applications and properties, more research and testing are required to fully understand the compound's properties and potential uses.

Upstream product

• 66003-76-7 Diphenyliodonium triflate 
• 557-01-7 2-hydroxypyrimidine 
• 557-01-7 Pyrimidin-2(1H)-one 
• 603-33-8 triphenylbismuthane 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 64-10-8 phenyl carbamate 

Downstream Products

• 16344-24-4 2-(phenylamino)nicotinic acid 
• 91815-77-9 3,6-dihydro-6-methoxycarbonylmethyl-1-phenyl-2(1H)-pyrimidinone 
• 91815-76-8 3,4-dihydro-4-methoxycarbonylmethyl-1-phenyl-2(1H)-pyrimidinone 
• 91815-79-1 3,6-dihydro-6-ethoxycarbonylmethyl-1-phenyl-2(1H)-pyrimidinone 
• 91815-78-0 3,4-dihydro-4-ethoxycarbonylmethyl-1-phenyl-2(1H)-pyrimidinone 
• 74057-02-6 1-isopropoxycarbonylamino-3-phenyliminoprop-1-ene 
• 74057-00-4 1-methoxycarbonylamino-3-phenyliminoprop-1-ene 
• 77942-49-5 3,6-dihydro-6-methyl-1-phenyl-2-(1H)pyrimidinone 
• 74057-01-5 1-ethoxycarbonylamino-3-phenyliminoprop-1-ene 
• 77942-34-8 4-methyl-1-phenyl-3,4-dihydropyrimidine-2(1H)-one 
• 91815-84-8 2-(2-Oxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-4-yl)-propionic acid ethyl ester 
• 10128-91-3 methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 27805-12-5 ethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 56535-85-4 3,4,5,6-tetrahydro-1-phenylpyrimidin-2(1H)-one 

Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

Phenylation of pyrimidinones using diphenyliodonium salts

Pyrimidinones 1 have been phenylated under basic conditions using diphenyliodonium salts, and the effect of substituents on the yield and regiochemistry has been studied. The Royal Society of Chemistry 1999.