177583-45-8Relevant articles and documents
Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy
Tucker, Thomas J.,Lumma, William C.,Lewis, S. Dale,Gardell, Stephen J.,Lucas, Bobby J.,Baskin, Elizabeth P.,Woltmann, Richard,Lynch, Joseph J.,Lyle, Elizabeth A.,Appleby, Sandra D.,Chen, I.-Wu,Dancheck, Kimberley B.,Vacca, Joseph P.
, p. 1565 - 1569 (1997)
In an effort to prepare orally bioavailable analogs of our previously reported thrombin inhibitor 1, we have synthesized a series of compounds that utilize the unique amino acid D-dicyclohexylalanine as a P3 ligand. The resulting compounds are extremely p
