17766-28-8 Usage
Description
1-Cyclohexylpiperazine is a chemical compound that serves as a ligand for both σ1 and σ2 receptors. It is characterized by its yellow-brownish appearance and low melting point, making it a versatile compound with potential applications in various fields.
Uses
1. Used in Pharmaceutical Industry:
1-Cyclohexylpiperazine is used as a receptor ligand for its diagnostic and therapeutic potentials. Its interaction with σ1 and σ2 receptors makes it a promising candidate for the development of new drugs and therapies targeting these receptors.
2. Used in Diagnostic Applications:
1-Cyclohexylpiperazine is used as a diagnostic tool to study the function and role of σ1 and σ2 receptors in various physiological and pathological processes. This can help in understanding the underlying mechanisms of certain diseases and conditions, leading to the development of more effective treatments.
3. Used in Research and Development:
As a σ1 and σ2 receptor ligand, 1-Cyclohexylpiperazine is used in research and development to explore the potential of these receptors in various therapeutic areas. This can lead to the discovery of new drug targets and the development of innovative treatments for a range of diseases and disorders.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7331, 1994 DOI: 10.1016/0040-4039(94)85306-1
Check Digit Verification of cas no
The CAS Registry Mumber 17766-28-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,6 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17766-28:
(7*1)+(6*7)+(5*7)+(4*6)+(3*6)+(2*2)+(1*8)=138
138 % 10 = 8
So 17766-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2/p+2
17766-28-8Relevant articles and documents
Preparation method of 1-cyclohexylpiperazine
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Paragraph 0031-0035, (2021/04/14)
The invention discloses a preparation method of 1-cyclohexylpiperazine. The method comprises the steps of carrying out reflux reaction on cyclohexyl halide, 1-Boc-piperazine and inorganic base in an organic solvent, filtering after the reaction is finished, and concentrating to obtain an intermediate 1; removing Boc from the intermediate 1 under an acidic condition, drying by distillation after the reaction is finished, pulping with isopropanol, and filtering to obtain solid 1-cyclohexyl piperazine hydrochloride; dissolving with water, adding an inorganic base to adjust the pH value to 12 to 14, extracting with an extraction solvent, drying the solvent by distillation to obtain a crude product of 1-cyclohexylpiperazine, and carrying out reduced pressure distillation on the crude product through an oil pump to obtain a pure product of 1-cyclohexylpiperazine. In the synthesis process of the intermediate 1, use of sodium triacetoxyborohydride and sodium hydroxide is avoided, the production cost is greatly saved, meanwhile, only filtering is needed for aftertreatment, the method is very simple, and time and labor are saved.
ANALGESIC THAT BINDS FILAMIN A
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Page/Page column 84; 85, (2010/05/14)
A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within.
