177703-80-9Relevant articles and documents
3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES
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Page/Page column 58; 77, (2016/04/04)
The present invention provides compounds of formula (I) (Formula (I)) and pharmaceutically acceptable salts thereof, wherein Q, X% X4,X5 X6, X7,R1, R2, R3 and R8 are as defined in the specification, processes for the preparation of such compounds, pharmaceutical compositions containing them and the use of such compounds in therapy.
A novel cyclopropanation
Bostick, Tracy Matthew,Christie, Sean D.,Connolly, Terrence Joseph,Copp, Steven,Langler, Richard Francis,Reid, Darren Leonard,Zaworotko, Michael
, p. 243 - 247 (2007/10/03)
Reaction between benzaldehyde and methyl α-benzylsulfonylacetate furnishes methyl (E)-α-benzylsulfonyl-β-phenylacrylate as the exclusive Knoevenagel adduct. The related condensations between α-benzylsulfonylacetonitrile and paraformaldehyde furnish trans-1-benzylsulfonyl-2-phenylcyclopropane-1-carbonitrile in modest yields. These product structures are established by X-ray crystallographic analysis. Phenylsulfene is ruled out as an intermediate in the formation of the cyclopropane.
