177727-25-2

Basic information

• Product Name: 1H-Pyrazole-1,5-diamine, 3-(1,1-dimethylethyl)-
• CAS NO: 177727-25-2
• Molecular Formula: C7H14N4
• Molecular Weight: 154.215
• Mol File: 177727-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-1,5-diamine, 3-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-1,5-diamine, 3-(1,1-dimethylethyl)-(177727-25-2)
• EPA Substance Registry System: 1H-Pyrazole-1,5-diamine, 3-(1,1-dimethylethyl)-(177727-25-2)

Safety Data

• Hazardous Substances Data: 177727-25-2(Hazardous Substances Data)

Usage

Physical form

white to off-white crystalline solid

Solubility

soluble in polar solvents

Use

in the synthesis of pharmaceutical compounds

Applications

potential use in the fields of medicine and biochemistry

Safety

handle with care, follow proper safety measures and guidelines during use and storage.

Upstream product

• 82560-12-1 3-tert-butyl-1H-pyrazole-5-amine 

Relevant articles and documents

Synthesis and chemistry of 3-tert-butyl-1,5-diaminopyrazole

N-Amination of 3-amino-5-tert-butylpyrazole 11 with hydroxylamine-O-sulfonic acid gave the 1,5-diaminopyrazole 12 with good regiochemical control. The reactions of 12 with certain electrophiles (e.g. acetic anhydride, DMF acetal, aromatic aldehydes, methoxymethylene Meldrum's acid) took place at one (or both) of the amino groups and no cyclised products were obtained. Reaction of 12 with carbon disulfide followed by alkylation under basic conditions provided the pyrazolo[1,5-b]1,2,4-triazole 26 which is a useful photographic magenta coupler. Reactions of 12 with 1,2- and 1,3-dicarbonyl compounds (diketones and ketoesters) provided new pyrazolo[1,5-b]1,2,4-triazines 29, 30, 42 and 43 and the first derivatives of the pyrazolo[1,5-b]1,2,4-triazepine system 31 and 35-36. The X-ray crystal structure of the pyrazolotriazepine 33 is reported.